红细胞在毛细血管中的运动特征分析  

Analysis on Motion Characteristics of Red Blood Cells in Capillaries

作　　者：刘德运 龚晓波[1] LIU Deyun;GONG Xiaobo(School of Naval Architecture,Ocean&Civil Engineering,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海交通大学船舶海洋与建筑工程学院,上海200240

出　　处：《医用生物力学》2023年第1期123-128,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(12072198);国家重点研发计划项目(2017YFE0117100)。

摘　　要：目的 探究不同力学特性的红细胞在毛细血管中的运动变形,对相关血液流变学参数进行分析。方法 红细胞膜为超弹性膜,满足Skalak能量函数。采用浸入边界法将细胞膜与流场耦合,采用二阶精度的有限差分方法求解三维流场。同时,考虑了细胞膜内外的生理黏度比λ=5。结果 得到在不同硬度下细胞在毛细血管中的稳定变形。随细胞硬度的升高,细胞由轴对称形态转变为非对称屈曲形态。细胞变形随着毛细血管数的降低而减弱,流动阻力增大。结论 细胞变硬,细胞出现非对称变形,血液阻力上升。因此,在涉及红细胞硬度变化的疾病中,变硬的红细胞可能导致毛细血管堵塞,造成局部组织缺氧。Objective To study the motion and deformation of red blood cells(RBCs) with different mechanical properties in capillaries,and make analysis on the associated hemorheological parameters.Methods The RBC was modeled as a hyper elastic membrane using Skalak model.The fluid was solved using a two-order finite difference scheme with the membrane mechanics treated by the immersed method.The pathological viscosity ratio λ=5 was considered.Results The steady deformation of RBCs with different membrane stiffness in the capillary was obtained.With membrane stiffness increasing,the cell transformed from axisymmetric shapes to non-axisymmetric shapes.With capillary number increasing,the deformability of RBCs weakened and the flow resistance increased.Conclusions With stiffening of cell membrane,the non-axisymmetric cell shape appears and the flow resistance increases.Therefore,in diseases involved stiffening RBCs,the stiffened RBCs can cause the blockage of capillaries and hypoxia in surrounding tissues.

关 键 词：红细胞 大变形 流固耦合 浸入边界法 毛细血管 非对称变形 

分 类 号：R318.01[医药卫生—生物医学工程]