单核细胞与高密度脂蛋白胆固醇比值预测肱动脉血流介导舒张功能减低  

The Monocyte to High-Density Lipoprotein Cholesterol Ratio in Predicting the Reduction of Brachial Artery Flow Mediated Dilation

作　　者：陈重泽 洪永强 杨如容 吴秀琴 陈新华 Chen Zhongze;Hong Yongqiang;Yang Rurong;Wu Xiuqin;Chen Xinhua(Department of Ultrasound,Mindong Hospital Affiliated to Fujian Medical University,Fuan,Fujian 355oo0,China)

机构地区：[1]福建医科大学附属闽东医院超声医学科,福建省福安市355000

出　　处：《中国超声医学杂志》2023年第3期321-324,共4页Chinese Journal of Ultrasound in Medicine

基　　金：2014年福建省医学创新课题(No.2014-CXB-25);2022年福建省自然科学基金项目(No.2022J011517)。

摘　　要：目的 探讨单核细胞与高密度脂蛋白胆固醇比值(MHR)对肱动脉血流介导舒张功能(FMD)减低的预测价值。方法 整体抽样闽东9个村庄最终纳入253名志愿者作为研究对象,男126名,女127名,收集所有研究对象的肱动脉FMD、血常规、血生化及相关基线资料。统计分析MHR和FMD、FMD≤10的关联性,MHR预测FMD≤10的效能。结果 ①多因素线性回归分析显示MHR与FMD之间存在独立关联(β=-0.166, 95%CI:-0.312~-0.020,P=0.026),多因素Logistic回归分析显示MHR与FMD≤10之间存在独立关联(OR 2.688, 95%CI:1.693~4.269,P<0.001);②以MHR预测FMD≤10的ROC曲线下面积为0.761,标准误为0.047,P<0.001,其最佳临界值为0.26,灵敏度为84.85%,特异度为62.01%,约登指数为0.47;以MHR≥0.26预测FMD≤10的OR值为7.36, 95%CI为2.885~18.705。结论 MHR是FMD减低的独立危险因素,MHR增高预测FMD减低,当MHR≥0.26时,对动脉内皮功能减低发生风险有一定的预测价值。Objective This study aimed to explore the predictive value of monocyte to high-density lipoprotein ratio(MHR) in the reduction of brachial artery flow mediated dilation(FMD). Methods A total of 253 people were included as research subjects, including 126 males and 127 females, which were selected from nine villages in eastern Fujian Province. The brachial artery FMD, routine blood test, blood biochemistry test and related baseline data of all subjects were collected. The correlation between MHR and FMD, FMD≤10, and the efficacy of MHR in predicting FMD≤10 were statistically analyzed. Results①Multivariate linear regression showed the independent association of MHR to FMD(β=-0.166, 95%CI:-0.312 to-0.020, P=0.026), and multivariate Logistic regression analysis showed the independent association of MHR to FMD≤10(OR=2.688, 95%CI:1.693 to 4.269, P<0.001).② The area under the receiver operating characteristic(ROC) curve of MHR for predicting FMD≤10 was 0.761 with the standard error of 0.047, P<0.001. The cut-off value of MHR was 0.26, with a sensitivity of 84.85%, a specificity of 62.01%, and a Youden index of 0.47. The OR value of MHR≥0.26 predicting FMD≤10 was 7.36 with 95%CI 2.885 to 18.705. Conclusions MHR is an independent risk factor for FMD reduction. Increased MHR predicted FMD reduction. When MHR≥0.26, it has a certain predictive value for the risk of reduced arterial endothelial function.

关 键 词：单核细胞与高密度脂蛋白胆固醇比值 血流介导舒张功能 肱动脉 内皮功能 

分 类 号：R543[医药卫生—心血管疾病]