血浆RAAS与重症急性胰腺炎患者炎症因子表达及肝肾功能指标的相关性分析  

Correlation of plasma RAAS with inflammatory cytokines expression and liver and kidney function in patients with severe acute pancreatitis

作　　者：杜立平[1] 张志永[1] DU Liping;ZHANG Zhiyong(Dept.of Nuclear Medicine,The Affiliated Hospital of Inner Mongolia Medical University,Huhhot O10050,Inner Mongolia,China)

机构地区：[1]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050

出　　处：《武汉大学学报（医学版）》2023年第2期206-209,233,共5页Medical Journal of Wuhan University

基　　金：内蒙古科技攻关项目(编号:201605025)。

摘　　要：目的:探讨血浆肾素-血管紧张素-醛固酮系统(RAAS)与重症急性胰腺炎患者炎症因子表达及肝肾功能指标的相关性。方法:选取2017年10月—2019年1月内蒙古医科大学附属医院收治的重症急性胰腺炎患者60例为观察对象。另选取同期体检的健康人60例为对照组。分别检测两组患者血浆RAAS相关指标水平、血清炎症因子水平、血清肝肾功能指标水平,并进行比较,同时予以Pearson相关性分析。结果:观察组肾素(Renin)、醛固酮(ALD)、血管紧张素Ⅱ(Ang-Ⅱ)、C-反应蛋白(CRP)、白细胞介素(IL)-6、IL-10以及肝肾功能指标水平均高于对照组(均P<0.05)。经Pearson相关性分析:重症急性胰腺炎患者血浆Renin、ALD、Ang-Ⅱ与CRP、IL-6、IL-10、碱性磷酸酶(ALP)、天冬氨酸氨基转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)、尿素氮(BUN)、血肌酐(Scr)、尿酸(UA)均成正相关(P<0.05)。观察组患者治疗后的APACHEⅡ评分仍高于对照组,但组间差异无统计学意义(P>0.05)。结论:重症急性胰腺炎患者存在明显的RAAS活性升高,且随着RAAS活性的不断升高患者炎症反应程度以及肝肾功能受损程度随之增加。Objective:To discuss the correlation between plasma renin-angiotensin-aldosterone system(RAAS)and the expression of inflammatory factors and liver and kidney function indexes in patients with severe acute pancreatitis.Methods:Sixty patients with severe acute pancreatitis admitted to The Affiliated Hospital of Inner Mongolia Medical University from October 2017 to January 2019 were selected into the observation group.Another 60 healthy people who had physical examination in our hospital during the same period were selected into the control group.The levels of plasma RAAS related indicators,serum inflammatory factors and serum liver and kidney function indicators were detected and compared between the two groups.Pearson correlation analysis was adopted to study the relation of RAAS related indicators with other indexes.Results:The levels of plasma renin(Renin),aldosterone(ALD),angiotensinⅡ(Ang-Ⅱ),serum C reactive protein(CRP),interleukin-6(IL-6),interleukin-10(IL-10),and all the serum liver and kidney function indexes in observation group were higher than in control group(all P<0.05).By Pearson correlation analysis,the levels of plasma Renin,ALD,and Ang-Ⅱwere corrlated positively to the levels of CRP,IL-6,IL-10,alkaline phosphatase(ALP),aspartate aminotransferase(AST),γ-glutamyltranspeptidase(γ-GT),urea nitrogen(BUN),blood creatinine(Scr),and uric acid(UA)in patients with severe acute pancreatitis(all P<0.05).The APACHEⅡscore of observation group was still higher than that of control group after treatment,but there was no significant difference between the two groups(P>0.05).Conclusion:There was a significant increase in RAAS activity in patients with severe acute pancreatitis,and the degree of inflammation and impairment of liver and kidney function increased with the increase of RAAS activity.

关 键 词：重症急性胰腺炎 肾素-血管紧张素-醛固酮系统 肝肾功能指标 

分 类 号：R657.51[医药卫生—外科学]