硫化氢延缓肾脏纤维化作用机制的研究进展  

Research progress on the mechanism of hydrogen sulfide delaying renal fibrosis

作　　者：李晨[1] 王惠明[1] LI Chen;WANG Huiming(Dept.of Nephrology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院肾内科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2023年第2期240-245,共6页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:81370800)。

摘　　要：肾脏纤维化是慢性肾脏病(CKD)最常见的表现,现有的治疗方法只能延缓慢性肾脏病的进展而不能治愈。因此,寻找新的治疗方法尤为重要。硫化氢(H_(2)S)作为一种新型内源性气体信号分子,在多种器官系统中发挥强大的细胞保护作用。大量研究表明,硫化氢可以通过抑制炎症、改善缺氧、抗氧化应激等机制来改善肾脏纤维化。本文综述了有关硫化氢延缓肾脏纤维化的相关作用机制,以期为硫化氢应用于肾脏纤维化的临床治疗提供新思路。Renal fibrosis is the most common manifestation of chronic kidney disease.Existing treatments can only delay the progression but can not cure it.Therefore,it is important to find new treatments.Hydrogen sulfide(H_(2)S),as a novel endogenous gas signaling molecule,plays a powerful cell-protective role in a variety of organ systems.Studies have shown that H_(2)S improves renal fibrosis by inflammation inhibition,hypoxia improvement,anti-oxidant responses,and other mechanisms.This article reviews the mechanism of hydrogen sulfide retarding renal fibrosis,in order to provide a new idea for the application of hydrogen sulfide in the clinical treatment of renal fibrosis.

关 键 词：硫化氢 肾脏纤维化 慢性肾脏病 

分 类 号：R692.6[医药卫生—泌尿科学]