植物SUMO化修饰研究进展  

Research Progress in Plant SUMOylation

作　　者：桑田 王鹏程 SANG Tian;WANG Peng-cheng(Institute of Advanced Biotechnology,Southern University of Science and Technology,Shenzhen 518055;Shanghai Center for Plant Stress Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai 201602)

机构地区：[1]南方科技大学前沿生物技术研究院,深圳518055 [2]中国科学院分子植物科学卓越创新中心,上海植物逆境生物学研究中心,上海201602

出　　处：《生物技术通报》2023年第3期1-12,共12页Biotechnology Bulletin

基　　金：国家重点研发计划项目(2021YFA130402)。

摘　　要：SUMO化修饰是一种高度保守的蛋白质翻译后修饰。在SUMO化酶系统的协同作用下,成熟的SUMO分子以异肽键的方式结合到靶蛋白上,调控靶蛋白稳定性、活性、定位等。同时,发生SUMO化修饰的蛋白在SUMO特异蛋白酶的作用下发生去SUMO化反应,使SUMO重新进入循环过程。已知SUMO化修饰参与了植物胁迫响应、生长发育、开花等重要生理过程的调控。本文主要介绍了植物SUMO化修饰途径及其调控的生物学过程,并讨论蛋白组学方法在SUMO化修饰底物鉴定的进展及问题。SUMOylation is a highly-conserved post-translational modification in eukaryotes.Under the synergistic work of the SUMOylase system,mature SUMO can covalently target to the lysine residue in substrate proteins in the form of iso-peptide bonds.The SUMOylation is highly dynamic and can regulate various biological processes by affecting target proteins' stability,activity,localization,etc.The conjugated SUMO molecular can be removed from its targets by SUMO proteases and re-enter the SUMO catalytic cycle.Reports indicate that SUMOylation is involved in stress response,growth,and flowering.In this review,we briefly summarize the current processes of the plant SUMOylation pathway and discusses the identification of SUMO tragets by biochemistry and proteomics strategies.

关 键 词：SUMO化修饰 生长发育 胁迫 蛋白组学 

分 类 号：Q943[生物学—植物学]