温敏型药物缓释载体制备及性能  

Preparation and Properties of Temperature-sensitive Drug SustainedRelease Carrier

作　　者：安可心 来士胜 张倩 尚宏周 乔宁 孙晓然 AN Ke-xin;LAI Shi-sheng;ZHANG Qian;SHANG Hong-zhou;QIAO Ning;SUN Xiao-ran(College of Chemical Engineering,North China University of Science and Technology,Tangshan Hebei 063210,China;College of Pharmacy,North China University of Science and Technology,Tangshan Hebei 063210,China;College of Materials Science and Engineering,North China University of Science and Technology,Tangshan Hebei 063210,China)

机构地区：[1]华北理工大学化学与工程学院,河北唐山063210 [2]华北理工大学药学院,河北唐山063210 [3]华北理工大学材料科学与工程学院,河北唐山063210

出　　处：《华北理工大学学报（自然科学版）》2023年第2期33-40,59,共9页Journal of North China University of Science and Technology：Natural Science Edition

基　　金：河北省属高校基本科研业务费项目(JYG2019003);唐山市功能高分子材料基础创新团队项目(21130201D)。

摘　　要：通过材料结构设计,制备一种具有核壳结构的温敏型药物缓释载体,实现药物的智能释放。以纳米介孔硅为基质,采用KH-570对其进行表面修饰引入双键,然后以N-异丙基丙烯酰胺(NIPAM)为功能单体,以槲皮素(QC)为模型药物,采用自由基聚合技术,制备核壳结构的温敏型药物载体(mSiO_(2)-NIPAM)。采用FTIR、BET、XRD、SEM和TEM等分析方法对其结构和性能进行了分析。结果表明,mSiO_(2)-NIPAM的最佳载药温度为25℃,此时载药率达46.25%、包封率为86.05%;体外释药实验显示,在42℃条件下,QC@mSiO_(2)-NIPAM在各时段的累积释药率均高于25℃条件下的累积释药率,说明其对疏水性药物具有优异的温度响应性能。Through material structure design,a temperature-sensitive drug sustained release carrier with a core-shell structure was prepared to realize the intelligent release of drugs.Nano porous silicon was used as the substrate,KH-570 was used for surface modification to introduce double bonds,and then N-isopropylacrylamide(NIPAM)was used as the functional monomer and quercetin(QC)was used as the model drug to prepare a core-shell structured temperature-sensitive drug carrier(mSiO_(2)-NIPAM)by free radical polymerization technique.The structure and properties were analyzed by FTIR,BET,XRD,SEM and TEM.The results of drug loading experiments show that the optimal drug loading temperature of mSiO_(2)-NIPAM is 25℃,and at this temperature,the drug loading rate reaches 46.25%and the encapsulation rate is 86.05%.In vitrodrug release experiments show that the cumulative release rate of QC@mSiO_(2)-NIPAM at 42℃is higher than that at 25℃in each period,indicating that it has an excellent temperature-sensitive performance to hydrophobic drugs.

关 键 词：温敏 药物缓释 槲皮素 纳米材料 

分 类 号：TQ460.4[化学工程—制药化工]