黑色素瘤缺乏因子-2炎症小体在感染中的作用机制研究进展  

Research progress on the mechanism of AIM2 inflammasome in infection

作　　者：何李华 江茜 刘英奇 谢璐 刘志平[3,4] HE Li-hua;JIANG Xi;LIU Ying-qi;XIE Lu;LIU Zhi-ping(Gannan Medical University,Ganzhou,Jiangxi 341000;Chinese Medical University,Shenyang,Liaoning 110000;School of Basic Medicine,Gannan Medical University;Immunology and Inflammation Center,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院,江西赣州341000 [2]中国医科大学,辽宁沈阳110000 [3]赣南医学院基础医学院 [4]赣南医学院炎症与免疫中心,江西赣州341000

出　　处：《赣南医学院学报》2023年第2期154-159,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(31960163);赣州市科技局项目(赣市科发【2019】60号);赣南医学院科技创新团队项目(TD201703,TD2021JC01);大学生实践创新训练计划项目(201910413003)。

摘　　要：黑色素瘤缺乏因子-2(Absent in melanoma-2,AIM2)是存在于细胞质中的模式识别受体,它能够识别内源性或外源性的双链DNA并组装一种称为炎症小体的蛋白聚合物,介导白介素-1β(Interleukin-1β,IL-1β)、白介素-18(Interleukin-18,IL-18)的成熟与释放,促使细胞发生炎症性的程序性死亡—细胞焦亡。AIM2对外源性DNA的识别有助于宿主抵抗各类病原微生物的感染,例如各种细菌、病毒、真菌以及寄生虫。本文就AIM2炎症小体在感染中的作用机制研究进展进行综述。Absent in melanoma-2(AIM-2)is a cytosolic innate pattern recognition receptor which binds to endogenous or exogenous double-stranded DNA and trigger the assembly of a multiprotein complex called the inflammasome.The inflammasome leads to the maturation and secretion of the interleukin-1β(IL-1β)and IL-18 as well as the induction of an programmed cell death called pyroptosis.The sensing of exogenous DNA by AIM2 has great significance in the host defense of pathogenic microorganism including bacteria,virus fungi and parasites.This article will focus on the research progress of the mechanism of AIM2 inflammasome in infection.

关 键 词：黑色素瘤缺乏因子-2 炎症小体 细胞焦亡 感染 

分 类 号：R392[医药卫生—免疫学]