哺乳动物微塑料暴露的毒理机制研究进展  

Mechanisms underlying the toxicity of microplastics to mammals:a review

作　　者：赵乾秀 白宇超 白淼 张灿(综述) 张传福(审校) ZHAO Qianxiu;BAI Yuchao;BAI Miao;ZHANG Can;ZHANG Chuanfu(School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China;Center for Disease Control and Prevention of Chinese PLA,Beijing 100071,China)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]解放军疾病预防控制中心,北京100071

出　　处：《预防医学》2023年第4期303-306,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：国家自然科学基金(52070193);北京市自然科学基金(8192053);保健专项(20BJZ17)。

摘　　要：微塑料作为一种新型环境污染物,广泛分布于全球生态系统中,机体摄入微塑料后可产生一系列毒性效应。本文基于现有研究文献,阐述了微塑料的主要暴露途径,从微塑料暴露导致的氧化应激、炎症反应、免疫损伤、菌群失调、能量代谢紊乱和DNA损伤等6个方面归纳了微塑料对哺乳动物的毒理机制,为进一步开展微塑料的毒理机制研究和健康风险评估提供参考。As a new type of environmental pollutants,microplastics are widely distributed in the global ecosystem,and ingestion of microplastics may produce a number of toxic effects.Based on currently available publications,this paper describes the main pathways of exposure to microplastics,and summarizes the toxic mechanisms of microplastics in mammals,including oxidative stress,inflammatory response,immune damage,imbalance of gut microbiota,energy metabo⁃lism disorder and DNA damage,so as to provide insights into elucidation of the toxic mechanism mechanisms and health risk assessment of microplastics.

关 键 词：微塑料 暴露途径 毒理机制 氧化应激 研究进展 

分 类 号：R114[医药卫生—卫生毒理学]