外周血宏基因组二代测序诊断人类免疫缺陷病毒合并耶氏肺孢子菌肺炎一例报告并文献复习  

A case report of diagnosis of human immunodeficiency virus complicated with pneumocystis yersini pneumonia by peripheral blood metagenomic sequencing and the literature reviewed

作　　者：陈飞 杨楠 邢彬 李霞 林俊岭[2] CHEN Fei;YANG Nan;XING Bin;LI Xia;LIN Junling(Department of Respiratory Medicine,Zhangjiakou First Hospital,Zhangjiakou 075000,China;Department of Respiratory and Critical Care Medicine,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]张家口市第一医院呼吸内科,张家口075000 [2]首都医科大学附属北京朝阳医院呼吸与危重症医学科,北京100020

出　　处：《中国研究型医院》2023年第1期50-52,共3页Chinese Research Hospitals

摘　　要：患者男,24岁,因发热、咳嗽、咳痰、全身酸痛20余天,加重伴喘憋5 d就诊。2021年12月16日住院诊治,经胸部平扫CT检查,见双肺弥漫片状高密度影;根据外周血淋巴细胞亚群分析结果诊断为人类免疫缺陷病毒(HIV);后通过检验外周血宏基因组二代测序(mNGS)确诊为耶氏肺孢子菌肺炎(PJP);给予复方新诺明治疗后,体温恢复正常,咳嗽、咳痰明显好转,出院。A 24-year-old male patient was admitted to the hospital due to fever,cough,expectoration,and body ache for more than 20 days,and he was aggravated by wheezing for 5 days.On December 16,2021,he was admitted to the hospital and was diagnosed with human immunodeficiency virus(HIV) based on the results of peripheral blood lymphocyte subset analysis and was seen to have diffuse patchy high-density shadows in both lungs on a chest CT scan. Then,the diagnosis of Pneumocystis jasinii pneumonia(PJP) was confirmed by peripheral blood metagenomic next-generation sequencing(mNGS). After symptomatic treatment with cotrimoxazole,his body temperature returned to normal,and his cough and sputum improved significantly. At last,the patient was discharged from the hospital.

关 键 词：人类免疫缺陷病毒 耶氏肺孢子菌肺炎 基因组测序 外周血 肺炎 

分 类 号：R563.1[医药卫生—呼吸系统] R512.91[医药卫生—内科学]