DNA杂化水凝胶的构建及性能  

Construction and Properties of DNA Hybrid Hydrogels

作　　者：张琦 孙锐 张瑜[1,2,3,4] 李霞 诸颖[1,2,3,4] ZHANG Qi;SUN Rui;ZHANG Yu;LI Xia;ZHU Ying(CAS Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China;University of Chinese Academy of Sciences,Beijing 100049,China;The Interdisciplinary Research Center,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China;Zhangjiang Laboratory,Shanghai 201210,China;School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 250059,China)

机构地区：[1]中国科学院上海应用物理研究所,中国科学院微观界面物理与探测重点实验室,上海201800 [2]中国科学院大学,北京100049 [3]中国科学院上海高等研究院基础交叉研究中心,上海201210 [4]张江实验室,上海201210 [5]聊城大学化学化工学院,聊城250059

出　　处：《高等学校化学学报》2023年第4期234-240,共7页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:82050005,22022410,12105352);上海市自然科学基金(批准号:22ZR1470600)资助。

摘　　要：以纯DNA水凝胶为主体,引入3种不同类型的杂化因子,依次对纯DNA水凝胶进行编码和结构改造,制备了DNA杂化水凝胶.研究了DNA杂化水凝胶的微观结构、机械性能和生物毒性.结果表明,二元编码因子(海藻酸钠/琼脂糖)DNA杂化水凝胶符合机械强度和生物安全效应双评价指标,生物安全性优异,且机械性能提高了3个数量级.本文研究结果为DNA水凝胶的编程改造提供了新思路,拓展了其在生物医学领域的应用.DNA hybrid hydrogels based on pure DNA hydrogels were prepared by selecting three different hybrid factors to encode and restructure pure DNA hydrogels successively.The microstructure,mechanical properties and biological toxicity of DNA hybrid hydrogels were characterized.The results showed that the bivariate coding factor(sodium alginate/agarose)DNA hybrid hydrogels could meet the double evaluation indexes of mechanical strength and biological safety effect,with excellent biological safety,and improved mechanical properties by three orders of magnitude.The result of this work provides a new idea for programming DNA hydrogels,which expands its applica⁃tion in biomedical field.

关 键 词：DNA杂化水凝胶 编码型 双评价指标 机械性能 生物医学应用 

分 类 号：O631[理学—高分子化学] O648[理学—化学]