氧化应激PET显像剂研究进展  

Progress of PET Probes for Oxidative Stress

作　　者：任书奇 傅丽兰 唐刚华[1] REN Shuqi;FU Lilan;TANG Ganghua(Department of Nuclear Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院核医学科PET中心,广州510515

出　　处：《同位素》2023年第2期259-269,I0008,共12页Journal of Isotopes

基　　金：国家自然科学基金重大研发计划(91949121);南方医院引进人才启动基金项目(123456)。

摘　　要：氧化应激被认为是许多疾病发生、发展和器官衰老的分子机制,包括各种肿瘤、神经退行性疾病等。高浓度活性氧(reactive oxygen species,ROS)可发生氧化应激导致蛋白质、脂质及DNA损伤。正电子发射断层显像(positron emission tomography,PET)是一种无创、定量、高灵敏的活体显像方法,能够在活体监测体内的ROS水平。鉴于氧化应激在疾病发生、发展中的重要作用,许多靶向氧化应激的显像剂被开发出来,包括直接与活性氧作用的小分子显像剂氢乙锭、氢甲锭类,参与合成体内抗氧化物的氨基酸类等,然而多数仍处于临床前评估阶段,氧化应激PET显像剂的临床转化是未来工作重点。本研究对氧化应激PET显像剂在临床前研究及临床常见疾病的最新进展进行综述,讨论各种探针的优缺点及局限性,并展望该领域的未来发展。Oxidative stress is assumed to be the principal molecularmechanism for the pathogenesis of organ aging and many diseases,including various tumors,neurodegenerative disorders and so on.Enhanced oxidative stress due to excess reactive oxygen species(ROS)generation leads to oxidative damage to the cellular components,such as proteins,lipids,and DNA.PET is a noninvasive,fully quantitative,and highly sensitive imaging modality that can detect ROS level in vivo.For important role of oxidative stress in diseases and aging,major ROS sensing probes have been developed,including hydroethidium(HE)and hydromethine(HM)analogue which has the ability to detect superoxide anion,and amino acids which have also been recognized as key components of cellular redox homeostasis.However,most of them are still in the preclinical studies,and the clinical transformation of oxidative stress PET imaging agents will be a major focus of future work.This review mainlyed describes the state of the art of Oxidative stress PET probes and their clinical applications in diagnosis of diseases.

关 键 词：氧化应激 正电子发射断层显像 放射性探针 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817[医药卫生—影像医学与核医学]