恩诺沙星可溶性粉在狼山鸡不同组织中的残留消除规律研究  

Residual Elimination of Enrofloxacin Soluble Powder in Different Tissues of Langshan Chicken

作　　者：王翠月 马丽娜[1,3] 周倩 唐修君[1,3] 张静 马尹鹏[1,3] 刘茵茵 陆俊贤[1,3] 陈大伟 高玉时 WANG Cuiyue;MA Lina;ZHOU Qian;TANG Xiujun;ZHANG Jing;MA Yinpeng;LIU Yinyin;LU Junxian;CHEN Dawei;GAO Yushi(Jiangsu Institute of Poultry Sciences,Yangzhou,Jiangsu 225125;Shandong Agricultural University,Tai′an,Shandong 271018;Ministry of Agriculture and Rural Affairs(Yangzhou),Yangzhou,Jiangsu 225125)

机构地区：[1]江苏省家禽科学研究所,江苏扬州225125 [2]山东农业大学,山东泰安271018 [3]农业农村部禽类产品质量安全风险评估实验室(扬州),江苏扬州225125

出　　处：《中国家禽》2023年第4期87-94,共8页China Poultry

基　　金：江苏现代农业(肉鸡)产业技术体系(JATS[2022]402);江苏省农业科技自主创新资金(CX(21)2011)。

摘　　要：为探究恩诺沙星及其代谢物环丙沙星在狼山鸡体内的残留消除规律,并确定其停药期,试验以狼山鸡为研究对象,恩诺沙星按10mg/kg体重的剂量饮水给药,连用5d,于最后一次给药后1、3、5、7、10和14d采集胸肌、肝脏、肾脏和皮脂样品,使用高效液相色谱串联质谱法检测样品中恩诺沙星及其代谢物环丙沙星的残留量。结果显示,停药后3d,狼山鸡各组织中药物残留量均低于其最大残留限量,狼山鸡胸肌、肝脏、肾脏和皮脂的停药期依次为2.91d、2.26d、3.62d和4.56d。结果表明,为保障狼山鸡食品安全,恩诺沙星的推荐停药期至少为5d。In order to investigate the elimination rule of enrofloxacin and its metabolite ciprofloxacin in chickens and its withdrawal period,Langshan chickens were administered consecutively given enrofloxacin in water at 10 mg/kg body weight for 5 days.Breast muscle,liver,kidney and sebum were collected at 1,3,5,7,10 and 14 days after drug withdrawal.The residues of enrofloxacin and its metabolite ciprofloxacin in the samples were determined by high performance liquid chromatography-tandem mass spectrometry.The results showed that the drug residues in all tissues were lower than maximum residue limit at 3rd day af⁃ter drug withdrawal,and the drug withdrawal periods of breast muscle,liver,kidney and sebum were 2.91,2.26,3.62 and 4.56 days,respectively.It′s suggested that in order to ensure food safety,the recommended withdrawal period of enrofloxacin for Lang⁃shan chicken should be at least 5 days.

关 键 词：恩诺沙星 狼山鸡 残留 停药期 

分 类 号：S859.84[农业科学—临床兽医学]