双酚A对孕妇及新生儿甲状腺功能的影响及作用机制研究进展  

Research progress on adverse effects of bisphenol A on thyroid function of pregnant women and neonates and its mechanism

作　　者：郝晓宇 孙丽聪 庄太凤[1] HAO Xiao-yu;SUN Li-cong;ZHUANG Tai-feng(Beijing Obstetrics&Gynecology Hospital,Capital Medical University/Beijing Maternal&Child Health Care Hospital.Beijing 100026)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院,北京100026

出　　处：《生殖医学杂志》2023年第4期638-643,共6页Journal of Reproductive Medicine

基　　金：环境化学与生态毒理学国家重点实验室(中国科学院生态环境研究中心)开放课题基金(KF2021-26)。

摘　　要：双酚A(bisphenol A,BPA)是一种典型的内分泌干扰物(endocrine disrupting chemicals,EDCs),广泛存在于人们日常生活中,对人体多种生理功能产生影响。甲状腺激素作为内分泌系统的重要组成部分,对于维持正常的新陈代谢及生长发育至关重要。BPA可以通过干扰甲状腺激素水平进而影响人体甲状腺功能。本文综述了人类相关的流行病学研究,深入了解BPA暴露对孕妇及新生儿甲状腺功能的影响及其作用机制,为限制BPA的应用提供更多的理论依据。Bisphenol A(BPA)is a typical endocrine disrupting chemicals(EDCs),which widely exists in people’s daily life and affects various physiological functions of the human body.As an important component of the endocrine system,thyroid hormone(TH)is critical to maintain human normal metabolism,growth and development.BPA can affect thyroid function by interfering with the level of human thyroid hormone.This article reviews the human related epidemiological studies,to deeply understand the impact of BPA exposure on thyroid function of pregnant women and neonates and its mechanism,so as to provide more theoretical basis for limiting the application of BPA.

关 键 词：双酚A 甲状腺激素 孕妇 新生儿 生长发育 

分 类 号：R17[医药卫生—妇幼卫生保健] R581[医药卫生—公共卫生与预防医学]