醋酸甲羟孕酮合成用钯炭催化剂研究  

Palladium-carbon catalyst for synthesis of medroxyprogesterone acetate

作　　者：翟康 张磊 王昭文 李岳锋 Zhai Kang;Zhang Lei;Wang Zhaowen;Li Yuefeng(Kaili Catalyst&New Materials Co.,Ltd.,Xi’an 710201,Shaanxi,China;Shaanxi Engineering Research Center of Noble Metal Catalyst,Xi’an 710201,Shaanxi,China;Shaanxi Key Laboratory of Catalytic Materials and Technology,Xi’an 710201,Shaanxi,China)

机构地区：[1]西安凯立新材料股份有限公司,陕西西安710201 [2]陕西省贵金属催化剂工程研究中心,陕西西安710201 [3]陕西省催化材料与技术重点实验室,陕西西安710201

出　　处：《工业催化》2023年第4期61-64,共4页Industrial Catalysis

摘　　要：以6-甲基孕酮乙酸酯为原料,在Pd/C催化剂和助剂等作用下合成醋酸甲羟孕酮。考察不同Pd含量催化剂及其用量、反应时间、反应温度、反应器转速对反应效果的影响。结果表明,制备的3%Pd/C和5%Pd/C催化剂均能实现醋酸甲羟孕酮的合成,3%Pd/C催化剂具有明显的性能和成本优势。在3%Pd/C催化剂用量1.0 g、反应温度100℃、反应时间90 min和反应器转速600 r·min^(-1)的条件下合成的醋酸甲羟孕酮纯度最优,对应粗品中F杂质最低。Using 6-methylene progesterone acetate as raw material,medroxyprogesterone acetate was synthesized under the action of Pd/C catalyst and additives.The effects of different dosage of catalyst with varying Pd contents,reaction time,reaction temperature and reaction speed on the synthesis of medroxyprogesterone acetate were investigated.The results show that the prepared 3%Pd/C and 5%Pd/C catalysts can realize the synthesis of medroxyprogesterone acetate,and the 3%Pd/C catalyst has obvious performance and cost advantages.Under the conditions of 3%Pd/C catalyst dosage of 1.0 g,reaction temperature of 100℃,reaction time of 90 min and reactor speed of 600 r·min^(-1),the purity of medroxyprogesterone acetate was the best,and the F impurity was the lowest in the corresponding crude product.

关 键 词：精细化学工程 醋酸甲羟孕酮 6-甲基孕酮乙酸酯 钯炭催化剂 

分 类 号：TQ426.6[化学工程] O643.36[理学—物理化学]