生长分化因子5 rs143383基因多态性与膝关节骨关节炎相关性的Meta分析  

Association between growth differentiation factor 5rs143383 gene polymorphism and knee osteoarthritis:a Meta-Analysis

作　　者：王月鹏 徐云峰 Wang Yuepeng;Xu Yunfeng(Graduate School,Changzhi Medical College,Changzhi 046000,China;Department of Orthopedics,Changzhi Yunfeng Hospital,Changzhi 046000,China)

机构地区：[1]长治医学院研究生处,046000 [2]长治云峰医院骨科,046000

出　　处：《中华老年骨科与康复电子杂志》2023年第1期51-58,共8页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：长治市科技局基金项目(2022sy008)。

摘　　要：目的探究生长分化因子5(GDF5)rs143383基因多态性与膝关节骨性关节炎发生的相关性。方法检索建库至2022年1月1日已经发表的关于GDF5 rs143383基因多态性与膝关节骨性关节炎之间相关性的文献,检索数据库包括PubMed、Embase、Web of Science、中国知网、万方和维普数据库等。依据检索策略检索,16篇文献(17项数据)符合纳入排除标准,从所需研究中提取数据后,确定优势比(OR)及其95%置信区间(CI)以评估。通过漏斗图评估发表偏差。结果GDF5(rs143383)基因多态性与膝关节骨性关节炎发生之间具有明显相关性。在总体的等位基因模型(T vs C:OR=1.20,95%CI:1.14,1.26,P<0.01)、共显基因模型(TT vs CC:OR=1.45,95%CI:1.30,1.62,P<0.01)和显性基因模型(TT+TC vs CC:OR=1.29,95%CI:1.17,1.43,P<0.01),均提示GDF5基因多态性与膝关节骨性关节炎的发生有明显相关性。此外,我们还根据种族进行亚组分型,通过亚组分析在亚洲人群以及高加索人群的等位基因模型(亚洲人群:T vs C:OR=1.22,95%CI:1.13,1.30,P<0.01;高加索人群:T vs C:OR=1.18,95%CI:1.10,1.26,P<0.01)、共显基因模型(亚洲人群:TT vs CC:OR=1.58,95%CI:1.33,1.88,P<0.01;高加索人群:TT vs CC:OR=1.37,95%CI:1.19,1.59,P<0.01)和显性基因模型(亚洲人群:TT+TC vs CC:OR=1.40,95%CI:1.18,1.65,P<0.01;高加索人群:TT+TC vs CC:OR=1.24,95%CI:1.08,1.42,P<0.01)中均观察到了GDF5 rs143383基因多态性与膝关节骨性关节炎发生显著的关联,然而在非洲人群中无明显关联。结论GDF5 rs143383基因多态性与膝关节骨性关节炎发生具有显著联系,尤其在亚洲人群和高加索人群中具有相关性。Objective To explore the relationship between growth differentiation factor 5(GDF5)rs143383 gene polymorphism and knee osteoarthritis(KOA).Methods The literatures about the relationship between GDF5 rs143383 gene polymorphism and knee osteoarthritis published from January 1,2022 were searched,including PubMed,Embase,Web of Science,China knowledge net,Wanfang and VIP database.According to the retrieval strategy,16 articles(17 items of data)met the inclusion exclusion criteria.After extracting the data from the required research,the odds ratio(OR)and its 95%confidence interval(CI)were determined for evaluation.The publication deviation was evaluated by funnel chart.Results We found that there was a significant correlation between GDF5 rs143383 gene polymorphism and knee osteoarthritis.In the overall allele model(T vs C:OR=1.29,95%CI:1.14,1.26,P<0.01),the codominant gene model(TT vs CC:OR=1.45,95%CI:1.30,1.62,P<0.01)and the dominant gene model(TT+TC vs CC:OR=1.29,95%CI:1.17,1.43,P<0.0l),it is suggested that there is a significant correlation between GDF5 gene polymorphism and the occurrence of knee osteoarthritis.In addition,we also subtyped according to race,through subgroup analysis of allele models in Asian and Caucasian populations(Asian population:T vs C: OR=1.22, 95% CI: 1.13, 1.30, P<0.01, Caucasian population: T vs C: OR=1.18, 95% CI: 1.10, 1.26, P<0.01)and codominant gene model (Asian population: TT vs CC: OR=1.58, 95% CI: 1.33, 1.88, P<0.01, Caucasianpopulation: TT vs CC: OR=1.37, 95% CI: 1.19, 1.59, P<0.01) and dominant gene model (Asian population:TT + TC vs CC: OR=1.40, 95% CI: 1.18, 1.65, P<0.01, Caucasian population: TT + TC vs CC: OR=1.24,95% CI: 1.08, 1.42, P<0.01). Significant association between GDF5 rs143383 gene polymorphism and kneeosteoarthritis was observed in Asian and Caucasian populations, but no significant association was found inAfrican population. Conclusion There is a significant association between GDF5 rs143383 gene polymorphismand knee osteoarthritis, especially in Asian and Caucas

关 键 词：生长分化因子5 rs143383 基因多态性 膝关节骨性关节炎 META分析 

分 类 号：R580[医药卫生—内分泌]