基于纳米材料的光学治疗在动脉粥样硬化性疾病中的应用与研究进展  

Current status and prospect of photo-therapy with nanomaterials for cardiovascular stenosis/obliterans disease induced by atherosclerosis

作　　者：席洋 张雷[3,4] 郭鹏程[3,4] 舒畅[3,4] 张毕奎 李焕德[1,2] 李鑫[3,4] XI Yang;ZHANG Lei;GUO Peng-cheng;SHU Chang;ZHANG Bi-kui;LI Huan-de;LI Xin(Department of Pharmacy,the Second Xiangya Hospital of Central South University,Changsha 410011;Institute of Clinical Pharmacy,Central South University,Changsha 410011;Department of Vascular Surgery,the Second Xiangya Hospital of Central South University,Changsha 410011;Institute of Vascular Diseases,Central South University,Changsha 410011)

机构地区：[1]中南大学湘雅二医院药学部,长沙410011 [2]中南大学临床药学研究所,长沙410011 [3]中南大学湘雅二医院血管外科,长沙410011 [4]中南大学血管病研究所,长沙410011

出　　处：《中南药学》2023年第3期721-725,共5页Central South Pharmacy

基　　金：国家自然科学基金项目(No.82120108005)。

摘　　要：动脉粥样硬化是由血管壁脂肪堆积引起的动脉壁慢性炎症反应,是引起心血管狭窄/闭塞性疾病的主要原因。然而目前临床上治疗动脉粥样硬化引起的冠状动脉或外周动脉狭窄/闭塞血管主要通过介入治疗,其存在易发生血管再狭窄和预防内膜增生的药效时间有限等缺点。然而随着纳米材料的兴起,无创的光学治疗为动脉狭窄/闭塞性疾病带来了新的机会。本文综述了近年来基于纳米材料的动脉粥样硬化相关光学治疗方法,并对其在临床治疗的应用前景做出展望。Atherosclerosis is a chronic inflammatory responses on the arterial wall from lipid deposition,the main cause of cardiovascular stenosis/obliterans disease.However,the current clinical interventional for coronary or peripheral artery stenosis/occlusion induced by atherosclerosis has some disadvantages,such as possible vascular restenosis and limited effect time to prevent intimal hyperplasia.However,with the rise of nanomaterials,non-invasive photo-therapy has brought new opportunities for arterial stenosi/occlusive diseases.This paper reviewed the recent photo-therapy with nanomaterials fo atherosclerosis based on and its prospect in clinical treatment.

关 键 词：动脉粥样硬化 动脉狭窄 动脉闭塞 纳米粒 光热治疗 光动力学治疗 

分 类 号：R94[医药卫生—药剂学]