心肺运动试验参数与射血分数保留的心力衰竭患者血清NT-proBNP、RDW水平的相关性  

Correlations among cardiopulmonary exercise test parameters and NT-proBNP and RDW levels in heart failure patients with preserved ejection fraction

作　　者：赵婕[1] 宋黄瑜 董欢欢[1] ZHAO Jie;SONG Huangyu;DONG Huanhuan(The 7th People’s Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市第七人民医院,河南郑州450000

出　　处：《中国民康医学》2023年第6期1-3,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析心肺运动试验(CPET)参数与射血分数保留的心力衰竭(HFpEF)患者血清N末端脑钠肽前体(NT-proBNP)、红细胞分布宽度(RDW)水平的相关性。方法:选取2019年5月至2021年4月该院收治的62例HFpEF患者为研究组,另取同期该院50名健康体检者为对照组。两组均进行CPET、心脏超声和实验室检查,比较两组临床资料、CPET参数[最大摄氧量(VO_(2)max)、最大自主通气量(MVV)、无氧阈(AT)]水平,采用Pearson相关性分析CPET参数与HFpEF患者血清NT-proBNP、RDW水平的相关性。结果:两组合并糖尿病、合并高血压占比和LVEF、LVEDD、RDW、NT-proBNP水平比较,差异均有统计学意义(P<0.05);研究组MVV、AT、VO_(2)max水平均低于对照组,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,AT、VO_(2)max、MVV与NTproBNP、RDW水平均呈负相关(r<0,P<0.05)。结论:HFpEF患者血清NT-proBNP、RDW水平均高于健康体检者,CPET参数与HFpEF患者NT-proBNP、RDW水平均呈负相关。Objective:To analyze correlations among cardiopulmonary exercise test(CPET)parameters and N-terminal pro-brain natriuretic peptide(NT-proBNP)and red blood cell distribution width(RDW)levels in heart failure patients with preserved ejection fraction(HFpEF).Methods:62 patients with HFpEF admitted to the hospital from May 2019 to April 2021 were selected as study group,and 50 healthy individuals from the hospital during the same period were selected as control group.Both groups underwent CPET,cardiac ultrasound,and laboratory examinations.The clinical data and the CPET parameters[maximum oxygen uptake(VO_(2)max),maximum voluntary ventilation volume(MVV),and anaerobic threshold(AT)]were compared between the two groups.Pearson correlation was used to analyze the correlations among the CPET parameters and the NT-proBNP and RDW levels in the HFpEF patients.Results:There were significant differences between the two groups in the diabetes,hypertension and the levels of LVEF,LVEDD,RDW,NT proBNP(P<0.05).The levels of MVV,AT,and VO_(2) max in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that AT,VO_(2)max,MVV were negatively correlated with the NTproBNP and RDW levels(r<0,P<0.05).Conclusions:The levels of NT-proBNP and RDW in the patients with HFpEF are higher than those in the healthy individuals.Further,the CPET parameters are negatively correlated with the NT-proBNP and RDW levels in the HFpEF patients.

关 键 词：射血分数保留的心力衰竭 心肺运动试验 红细胞分布宽度 N末端脑钠肽前体 最大摄氧量 最大自主通气量 无氧阈 

分 类 号：R541.6[医药卫生—心血管疾病]