HIF-1α在新生儿缺血缺氧性脑病中的研究进展  

Research progress on hypoxia-inducible factor-1αin the neonatal hypoxic-ischemic encephalopathy

作　　者：李蓓[1] 王路瑶 唐轶珣 孔高茵[1] LI Bei;WANG Luyao;TANG Yixun;KONG Gaoyin(Department of Anesthesiology,the First Affiliated Hospital of Hunan Normal University,Hunan People􀆳s Hospital,Changsha 410000,Hunan,China)

机构地区：[1]湖南师范大学附属第一医院、湖南省人民医院麻醉医学中心,湖南长沙410000

出　　处：《中南医学科学杂志》2023年第2期309-312,共4页Medical Science Journal of Central South China

基　　金：湖南省卫健委项目(20200758)。

摘　　要：新生儿缺血缺氧性脑病(NHIE)是指由于围产期多种不良因素引起患儿大脑部分或完全缺氧以及脑血流减少所导致的脑损伤疾病。缺氧诱导因子-1α(HIF-1α)是调节细胞适应缺氧环境的转录因子。在NHIE中,HIF-1α的表达对神经功能具有双向调节作用,主要与大脑缺血缺氧时间和程度有关。本文综述HIF-1α调控下游基因在NHIE中的具体机制。Neonatal hypoxic-ischemic encephalopathy(NHIE)refers to the brain injury disease caused by partial or complete hypoxia and decreased cerebral blood flow in newborn due to various adverse factors in the perinatal period.Hypoxia-inducible factor-1α(HIF-1α)is a transcription factor that plays a key role in cellular adaptation to a hypoxic environment.In NHIE,HIF-1αhas bidirectional effects on neurological function due to different duration and degree of cerebral ischemia and hypoxia.This article mainly describes HIF-1αRegulate the specific mechanism of downstream genes in NHIE.

关 键 词：缺氧诱导因子-Α 新生儿 缺血缺氧性脑病 

分 类 号：R722.1[医药卫生—儿科]