环境介质对微生物群体感应信号分子的影响  

Influences of environmental substrates on microbial quorum-sensing signals

作　　者：程阳眷 黄丹[1,2] 王玉璠 汪美贞 CHENG Yang-juan;HUANG Dan;WANG Yu-fan;WANG Mei-zhen(School of Environmental Science and Engineering,Zhejiang Gongshang University,Hangzhou 310012,China;Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling,Hangzhou 310012,China)

机构地区：[1]浙江工商大学环境与工程学院,浙江杭州310012 [2]浙江省固体废物处理与资源化重点实验室,浙江杭州310012

出　　处：《中国环境科学》2023年第4期2007-2016,共10页China Environmental Science

基　　金：国家重点研发计划项目(2018YFE0110500);国家自然科学基金资助项目(U21A20292);国家自然科学基金资助项目(42107035)。

摘　　要：群体感应(QS)是一种细菌谈话机制,指微生物通过释放信号分子进行细胞间交流,调控自由基释放、生物膜形成、基因水平转移等一系列群体行为.环境中广泛存在或使用的介质材料与信号分子相互作用进而影响这些群体行为.关于群体感应信号分子及其调控机制的综述很多,但却尚未有环境介质对胞内外信号分子影响的总结.本研究综述了微生物各类信号分子理化性质和生物功能,分析并总结了土壤矿物、纳米材料、生物炭和天然小分子化合物等环境介质对信号分子的影响,阐明了信号分子与环境介质之间的构-效关系,以期为深入理解真实环境中微生物群体感应调控行为提供重要参考.Quorum sensing(QS)is a bacterial conversation mechanism that regulates free radical release,biofilm formation,and gene level transfer by releasing signaling molecules for intercellular communication.The media materials widely present in the environment can interact with signaling molecules and thus influence the behavior of microorganism populations.Although there are many reviews on QS signal molecules and their regulatory mechanisms,the effects of environmental substrates on intracellular and extracellular signal molecules have not been well synthesized.Therefore,this study aims to elucidate the structure-function relationships between signal molecules and environmental substrates by reviewing the physicochemical properties and biological functions of various signal molecules of microorganisms and evaluating the effects of environmental substrates,such as soil minerals,nanomaterials,biochar and natural small molecule compounds,on signal molecules,so as to provide a vital reference for the in-depth understanding of the QS regulation of microbial communities in a realistic environment.

关 键 词：群体感应 信号分子 环境介质 构-效关系 相互作用 

分 类 号：X705[环境科学与工程—环境工程]