不同运动方式联合氟比洛芬凝胶贴膏在膝骨关节炎中的应用效果比较  

Comparison of application effect of different exercise modes combined with Flubiprofen Gel Paste in knee osteoarthritis

作　　者：程小桂 扶忠超 潘文天 史冉庚[2] 曹伟灵[1] CHENG Xiaogui;FU Zhongchao;PAN Wentian;SHI Rangeng;CAO Weiling(Department of Pharmacy,Luohu People's Hospital of Shenzhen City,Guangdong Province,Shenzhen 518001,China;Department of Rheumatology and Immunology,Luohu People's Hospital of Shenzhen City,Guangdong Province,Shenzhen 518001,China;Department of Pharmacy,Guangdong Pharmaceutical University,Guangdong Province,Guangzhou 510006,China)

机构地区：[1]深圳市罗湖区人民医院药学部,广东深圳518001 [2]深圳市罗湖区人民医院风湿免疫科,广东深圳518001 [3]广东药科大学药学系,广东广州510006

出　　处：《中国当代医药》2023年第11期76-80,共5页China Modern Medicine

基　　金：广东省临床用药研究基金(外科药学骨科镇痛专项基金)项目(2021ZT07);广东省深圳市罗湖区软科学研究计划项目(LX20211004)。

摘　　要：目的比较不同运动方式联合氟比洛芬凝胶贴膏在膝骨关节炎(KOA)中的应用效果。方法选取2021年9月至2022年1月深圳市罗湖区人民医院收治的50例KOA患者,按照随机数字表法分为五组,每组各10例。A组为常规干预,采用氟比洛芬凝胶贴膏。其余4组为运动干预,均在使用氟比洛芬凝胶贴膏基础上,每周运动3次。其中B组:步行30 min/次;C组:步行45 min/次;D组:跑步30 min/次;E组:跑步45 min/次;比较五组患者干预前后的视觉模拟评分(VAS)、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分及检测血清脂氧素A4(LXA4)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的浓度。结果各组患者干预后的VAS、WOMAC评分均低于本组干预前,差异有统计学意义(P<0.05);B、C、D、E组患者干预后的VAS、WOMAC评分均低于A组,差异有统计学意义(P<0.05);B、C、E组患者干预后的VAS、WOMAC评分均高于D组,差异有统计学意义(P<0.05)。五组患者干预后的血清LXA4、IL-1β、TNF-α水平比较,差异有统计学意义(P<0.05);A组干预后的血清LXA4低于D组,差异有统计学意义(P<0.05);A组干预后的血清IL-1β、TNF-α高于B、C、D、E组,差异有统计学意义(P<0.05);D组干预后的血清TNF-α低于A、B、C、E组,差异有统计学意义(P<0.05);B、C、D、E组干预后的血清LXA4高于本组干预前,差异有统计学意义(P<0.05);B、C、D、E组干预后血清IL-1β、TNF-α低于本组干预前,差异有统计学意义(P<0.05)。结论运动联合氟比洛芬凝胶贴膏治疗KOA比单用外用药的疗效和抗炎效果更佳,且每周3次跑步30 min作用更佳。运动可升高LXA4水平,降低IL-1β、TNF-α水平。Objective To compare the application effect of different exercise modes combined with Flubiprofen Gel Paste in knee osteoarthritis(KOA).Methods A total of 50 patients with KOA admitted to Luohu People's Hospital of Shenzhen City from September 2021 to January 2022 were selected and divided into 5 groups according to the random number table method,with 10 patients in each group.Group A was the conventional intervention,and Flurbiprofen Gel Paste was used.The other four groups were the exercise intervention,and they all exercised 3 times a week on the basis of Flurbiprofen Gel Paste.Group B:walking for 30 min each time,group C:walking for 45 min each time,group D:running for 30 min each time,group E:running for 45 min each time.The visual analogue scale(VAS)score,Western Ontario and McMaster University Osteoarthritis Index(WOMAC)score and serum lipoxin A4(LXA4),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)concentrations were compared between the five groups before and after intervention.Results The VAS and WOMAC scores of patients in each group after intervention were lower than those before intervention,and the differences were statistically significant(P<0.05).The VAS and WOMAC scores of patients in group B,C,D and E after intervention were lower than those in group A, and the differences were statistically significant (P<0.05). The VAS and WOMAC scores of group B, C and E after intervention were higher than those of group D, and the differences were statistically significant (P<0.05). There were statistically significant differences in the levels of serum LXA4, IL-1β and TNF-α among the five groups after intervention (P<0.05). The serum LXA4 of group A after intervention was lower than that of group D, and the difference was statistically significant (P<0.05). The serum levels of IL-1β and TNF-α in group A after intervention were higher than those in groups B, C, D and E, and the differences were statistically significant (P<0.05). The serum TNF-α of group D after intervention was lower than t

关 键 词：膝骨关节炎 运动治疗 脂氧素A4 白细胞介素-1Β 肿瘤坏死因子-Α 疼痛 

分 类 号：R684.3[医药卫生—骨科学]