两种促排卵方案对门诊诱导排卵治疗的临床研究  

Clinical study of two ovulation induction regimens in the treatment of outpatient induced ovulation

作　　者：彭伟 李清 刘珍 段超群 邓星 韩艳 PENG Wei;LI Qing;LIU Zhen;DUAN Chaoqun;DENG Xing;HAN Yan(Department of Reproduction,Yichun Maternal and Child Health Hospital,Jiangxi Province,Yichun336000,China)

机构地区：[1]江西省宜春市妇幼保健院辅助生殖科,江西宜春336000

出　　处：《中国当代医药》2023年第11期116-119,共4页China Modern Medicine

基　　金：江西省宜春市科技计划项目(JXYC2021KSA036)。

摘　　要：目的比较两种促排卵的方案对门诊诱导排卵治疗的临床疗效,探索诱导排卵的规范治疗方案。方法选择2018年1月至2021年6月在宜春市妇幼保健院门诊进行诱导排卵治疗的266例不孕患者为研究对象,按照诱导排卵方式分为固定给药组(采用固定给药诱导排卵治疗)139例(139周期)和传统给药组(采用传统给药诱导排卵治疗)127例(127周期)。比较两组患者人绒毛膜促性腺素(HCG)扳机日子宫内膜厚度、排卵效果、周期取消率、临床妊娠率及卵巢过度刺激综合征(OHSS)发生率。结果固定给药组患者HCG扳机日子宫内膜厚度大于传统给药组,差异有统计学意义(P<0.05);固定给药组周期取消率低于传统给药组,排卵率高于传统给药组,直径≥1.4 cm卵泡数量多于传统给药组,差异有统计学意义(P<0.05);固定给药组临床妊娠率高于传统给药组,差异有统计学意义(P<0.05);两组多胎妊娠率比较,差异无统计学意义(P>0.05)。结论固定给药方案可以降低诱导排卵的周期取消率,安全有效地提升患者排卵率和妊娠率。Objective To compare the clinical effect of two kinds of ovulation induction schemes on outpatient ovulation induction therapy,and explore the standard treatment scheme of ovulation induction.Methods A total of 266 infertile patients who underwent ovulation induction treatment in the outpatient department of Yichun Maternal and Child Health Hospital from January 2018 to June 2021 were selected as the study subjects.They were divided into 139 cases(139 cycles)in the fixed administration group(used fixed drug induction ovulation treatment)and 127 cases(127 cycles)in the traditional administration group(used traditional drug induction ovulation treatment)according to ovulation induction mode.Human chorionic gonadotropin(HCG)trigger day endometrial thickness,ovulation effect,cycle cancellation rate,clinical pregnancy rate and incidence of ovarian hyperstimulation syndrome(OHSS)were compared between the two groups.Results The endometrial thickness of the patients in the fixed administration group on the trigger day of HCG was greater than that of the traditional administration group,the difference was statistically significant(P<0.05).The cycle cancellation rate in fixed administration group was lower than that in the traditional administration group,and the ovulation rate was higher than that in the traditional administration group,the number of follicles with diameter≥1.4 cm was more than that in the traditional administration group,with significant differences(P<0.05).The clinical pregnancy rate of the fixed administration group was higher than that of the traditional administration group,the difference was statistically significant(P<0.05),and there was no significant difference in the multiple pregnancy rate between the two groups(P>0.05).Conclusion The fixed dosing regimen can reduce the cycle cancellation rate of ovulation induction and increase the ovulation rate and pregnancy rate of patients safely and effectively.

关 键 词：诱导排卵 固定给药促排卵 排卵率 妊娠率 

分 类 号：R711[医药卫生—妇产科学]