冠心病患者血清载脂蛋白B、载脂蛋白A1及其比值与血压的关系  

Relationship between serum apolipoprotein B,apolipoprotein A1 and their ratio and blood pressure in patients with coronary heart disease

作　　者：王静 丁水林 郭立富 WANG Jing;DING Shuilin;GUO Lifu(Department of Laboratory,Ganzhou Maternal and Child Health Hospital,Jiangxi Province,Ganzhou341000,China;Department of Laboratory,Ganzhou People's Hospital,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市妇幼保健院检验科,江西赣州341000 [2]江西省赣州市人民医院检验科,江西赣州341000

出　　处：《中国当代医药》2023年第11期154-156,167,共4页China Modern Medicine

基　　金：江西省赣州市科技计划项目(GZ2021ZSF289)。

摘　　要：目的探讨冠心病患者血清载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)及其比值与血压的关系。方法选取2019年1月至2022年8月赣州市人民医院收治的100例冠心病患者作为观察组,另选赣州市人民医院同期收治的100例非冠心病患者作为对照组,均采血检测ApoA1、ApoB水平,并计算ApoB/ApoA1。比较两组患者的ApoA1、ApoB、ApoB/ApoA1、收缩压、舒张压水平,采用Pearson相关性分析血清ApoA1、ApoB、ApoB/ApoA1与收缩压、舒张压的相关性。结果观察组患者的ApoA1低于对照组,ApoB、ApoB/ApoA1高于对照组,差异有统计学意义(P<0.05)。观察组患者的收缩压、舒张压高于对照组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,ApoA1水平与收缩压、舒张压呈负相关(P<0.001);ApoB、ApoB/ApoA1与收缩压、舒张压呈正相关(P<0.001)。结论冠心病患者血清内载脂蛋白与血压存在明显相关性,ApoA1越低、ApoB及ApoB/ApoA1越高则血压越高,临床可加强载脂蛋白与血压水平检测,便于冠心病的早期防治。Objective To investigate the relationship between serum apolipoprotein B(ApoB),apolipoprotein A1(ApoA1)and blood pressure in patients with coronary heart disease.Methods A total of 100 patients with coronary heart disease admitted to Ganzhou People's Hospital from January 2019 to August 2022 were selected as the observation group,and 100 non coronary heart disease patients admitted to Ganzhou People's Hospital at the same time were selected as the control group.Blood was collected to detect the level of ApoA1 and ApoB,and ApoB/ApoA1 was calculated.The levels of ApoA1,ApoB,ApoB/ApoA1,systolic blood pressure and diastolic blood pressure were compared between the two groups.Pearson correlation was used to analyze the correlation between serum ApoA1,ApoB,ApoB/ApoA1 and systolic blood pressure and diastolic blood pressure.Results ApoA1 in the observation group was lower than that in the control group,and ApoB and ApoB/ApoA1 were higher than those in the control group,with statistically significant differences(P<0.05).The systolic blood pressure and diastolic blood pressure in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that ApoA1 level was negatively correlated with systolic and diastolic blood pressure(P<0.001).ApoB and ApoB/ApoA1 were positively correlated with systolic and diastolic blood pressure(P<0.001).Conclusion There is a significant correlation between serum apolipoprotein and blood pressure in patients with coronary heart disease.The lower the ApoA1,the higher the ApoB and ApoB/ApoA1,the higher the blood pressure.Clinical detection of apolipoprotein and blood pressure can be strengthened to facilitate the early prevention and treatment of coronary heart disease.

关 键 词：冠心病 载脂蛋白 血压 相关性 

分 类 号：R446.1[医药卫生—诊断学]