Effects of gradient high-field static magnetic fields on diabetic mice  

作　　者：Biao Yu Chao Song Chuan-Lin Feng Jing Zhang Ying Wang Yi-Ming Zhu Lei Zhang Xin-Miao Ji Xiao-Fei Tian Guo-Feng Cheng Wei-Li Chen Vitalii Zablotskii Hua Wang Xin Zhang 

机构地区：[1]High Magnetic Field Laboratory,CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,Anhui 230031,China [2]Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230026,China [3]Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui,230601,China [4]Institute of Physics of the Czech Academy of Sciences,Prague,18221,Czech Republic [5]Department of Oncology,First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China [6]International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China

出　　处：《Zoological Research》2023年第2期249-258,共10页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China (U21A20148, 31900506, 52007185);International Partnership Program of the Chinese Academy of Sciences(116134KYSB20210052);Heye Health Technology Chong Ming Project(HYCMP2021010);CAS President’s International Fellowship Initiative Grant(2022VMA0009);CASHIPS Director’s Fund (BJPY2021A06,2021YZGH04, YZJJ2020QN26, YZJJZX202014, YZJJ2021QN32,YZJJ2023QN43)。

摘　　要：Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.

关 键 词：Type 2 diabetes Type 1 diabetes Magnetic resonance imaging(MRI) Gradient static magnetic field Quasi-uniform static magnetic field 

分 类 号：R587.1[医药卫生—内分泌] R445.2[医药卫生—内科学] R-332[医药卫生—临床医学]