Adult neurogenesis in the primate hippocampus  

作　　者：Ye Li Na-Na Xu Zhao-Zhe Hao Sheng Liu 

机构地区：[1]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510060,China [2]Guangdong Province Key Laboratory of Brain Function and Disease,Guangzhou,Guangdong 510080,China

出　　处：《Zoological Research》2023年第2期315-322,共8页动物学研究（英文）

基　　金：supported by the Natural Science Foundation of China (81961128021, 81870682);National Key R&D Program of China (2022YEF0203200);Guangdong Provincial Key R&D Programs (2018B030335001);Science and Technology Program of Guangzhou (202007030011, 202007030010,202007030001)。

摘　　要：Adult hippocampal neurogenesis(AHN) is crucial for learning,memory,and emotion.Deficits of AHN may lead to reduced cognitive abilities and neurodegenerative disorders,such as Alzheimer’s disease.Extensive studies on rodent AHN have clarified the developmental and maturation processes of adult neural stem/progenitor cells.However,to what extent these findings apply to primates remains controversial.Recent advances in next-generation sequencing technologies have enabled in-depth investigation of the transcriptome of AHN-related populations at single-cell resolution.Here,we summarize studies of AHN in primates.Results suggest that neurogenesis is largely shared across species,but substantial differences also exist.Marker gene expression patterns in primates differ from those of rodents.Compared with rodents,the primate hippocampus has a higher proportion of immature dentate granule cells and a longer maturation period of newly generated granule cells.Future research on species divergence may deepen our understanding of the mechanisms underlying adult neurogenesis in primates.

关 键 词：Neural precursor cells Immature granule cells Sc-RNA-seq 

分 类 号：Q42[生物学—神经生物学]