Ferrets: A powerful model of SARS-CoV-2  

作　　者：Yan Zhao Chang-Le Wang Zhi-Yun Gao Hong-Xiu Qiao Wei-Jie Wang Xin-Yan Liu Xia Chuai 

机构地区：[1]Department of Pathogenic Biology,Hebei Medical University,Shijiazhuang,Hebei 050017,China [2]Institute of Medicine and Healthy of Hebei Medical University,Shijiazhuang,Hebei 050017,China [3]Department of Oncology,Hebei Provincial Thoracic Hospital,Shijiazhuang,Hebei 050010,China

出　　处：《Zoological Research》2023年第2期323-330,共8页动物学研究（英文）

基　　金：supported by the S&T Program of Hebei(20277705D and 20372601D);Natural Science Foundation of Hebei Province,China (H2020206352);Science and Technology Project of Hebei Education Department (QN2018150);Hebei Medical Science Research Project (20220973);Chinese Medicine Research Program of Hebei Province (2021119)。

摘　　要：The rapid spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) in recent years not only caused a global pandemic but resulted in enormous social,economic,and health burdens worldwide.Despite considerable efforts to combat coronavirus disease 2019(COVID-19),various SARS-CoV-2 variants have emerged,and their underlying mechanisms of pathogenicity remain largely unknown.Furthermore,effective therapeutic drugs are still under development.Thus,an ideal animal model is crucial for studying the pathogenesis of COVID-19 and for the preclinical evaluation of vaccines and antivirals against SARS-CoV-2 and variant infections.Currently,several animal models,including mice,hamsters,ferrets,and nonhuman primates(NHPs),have been established to study COVID-19.Among them,ferrets are naturally susceptible to SARS-CoV-2 infection and are considered suitable for COVID-19 study.Here,we summarize recent developments and application of SARS-CoV-2 ferret models in studies on pathogenesis,therapeutic agents,and vaccines,and provide a perspective on the role of these models in preventing COVID-19 spread.

关 键 词：SARS-CoV-2 COVID-19 Animal models FERRET Angiotensin-converting enzyme 2(ACE2)receptor 

分 类 号：R511[医药卫生—内科学] R-332[医药卫生—临床医学]