纤维蛋白降解产物等凝血指标与严重烧伤休克患者预后的相关性  

Correlation between Coagulation Indicators Such as Fibrin Degradation Products and the Prognosis of Patients with Severe Burn Shock

作　　者：郭雪鹏 尹明明 王国辉 周波 李永强 庹章强 GUO Xue-peng;YIN Ming-ming;WANG Guo-hui(Department of Burn Microsurgery,People's Hospital of Ankang,Ankang Shaanxi 725000)

机构地区：[1]安康市人民医院烧伤显微外科,陕西安康725000

出　　处：《医学临床研究》2023年第3期421-424,共4页Journal of Clinical Research

摘　　要：【目的】探讨纤维蛋白降解产物(FDP)等凝血指标与严重烧伤休克患者预后的相关性。【方法】选取本院收治的91例严重烧伤休克患者为研究对象,收集其基本资料及入院时FDP等凝血指标情况,患者治疗后随访60 d统计其生存情况。分析影响患者预后的因素及凝血指标预测患者预后的价值。【结果】91例严重烧伤休克患者随访期间死亡33例(死亡组),占36.26%(33/91),其余58例(63.74%,58/91)生存(生存组)。Logistic因素回归分析显示,急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)评分、烧伤总面积、活化部分凝血活酶时间(APTT)、FDP是影响患者预后的独立因素(P<0.05)。受试者工作特征(ROC)曲线结果显示,FDP、APTT及二者联合预测严重烧伤休克患者预后的灵敏度分别为72.72%、75.76%、72.72%,特异度分别为72.41%、70.69%、96.55%,曲线下面积(AUC)分别为0.762、0.774、0.905。【结论】严重烧伤休克患者预后不良风险较高,FDP、APTT与患者预后有关,二者联合预测对患者的预后效能良好。【Objective】To explore the correlation between coagulation indicators such as fibrin degradation products and the prognosis of patients with severe burn shock:the early warning value of fibrin degradation products(FDP)and coagulation indexes for the prognosis of patients with severe burn shock.【Methods】A total of 91 patients with severe burn shock admitted to our hospital were selected as the research objects.The basic information of all patients and coagulation indexes such as FDP at admission were collected.The patients were followed up for 60 days after treatment to calculate their survival.Factors affecting the prognosis of patients and value of coagulation indexes in predicting the prognosis of patients were analyzed.【Results】During the follow-up period of 91 severe burn shock patients,33 cases died(36.26%,33/91),and the remaining 58 cases(63.74%,58/91)survived.Logistic regression analysis showed that acute physiology and chronic health status scoreⅡ(APACHEⅡ),total burn area,activation partial thromboplastin time(APTT),and FDP were independent factors affecting the prognosis of patients(P<0.05).The ROC curve results showed that the sensitivities of FDP,APTT and their combination to predict the prognosis of patients with severe burn shock were 72.72%,75.76%and 72.72%,respectively,while the specificities were 72.41%,70.69%,and 96.55%,respectively,and the AUC were 0.762,0.774,and 0.905,respectively.【Conclusion】Patients with severe burn shock are at higher risk of poor prognosis.FDP and APTT are related to the prognosis of patients with severe burn shock.The combination of the two has a good prognostic value in predicting the prognosis.

关 键 词：烧伤 休克 纤维蛋白纤维蛋白原降解物 预后 

分 类 号：R644[医药卫生—外科学]