人工牛黄甲硝唑胶囊联合多西环素治疗慢性牙周炎的疗效及对龈沟液和血清中RANKL、MMP-8、NE、sICAM-1水平的影响  

Efficacy of Artificial Bezoar Metronidazole Capsules Combined with Doxycycline in the Treatment of Chronic Periodontitis and Its Effects on RANKL,MMP-8,NE and sICAM-1 Levels in Gingival Crevicular Fluid and Serum

作　　者：高尚 熊伯刚 冯培明 陈莉[2] 王洁[3] GAO Shang;XIONG Bogang;FENG Peiming;CHEN Li;WANG Jie(Dept.of Stomatology,Beijing Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100039,China;Dept.of Stomatology,Beijing Stomatological Hospital Affiliated to Capital Medical University,Beijing 100050,China;Dept.of Stomatology,Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]北京中西医结合医院口腔科,北京100039 [2]首都医科大学附属北京口腔医院口腔科,北京100050 [3]航天中心医院口腔科,北京100049

出　　处：《中国医院用药评价与分析》2023年第3期317-320,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：航天医科2020年科研项目(No.2020YK17)。

摘　　要：目的:探讨人工牛黄甲硝唑胶囊联合多西环素治疗慢性牙周炎(CP)的临床疗效及其对患者龈沟液和血清中核因子κB受体活化因子配体(RANKL)、基质金属蛋白酶8(MMP-8)、中性粒细胞弹性蛋白酶(NE)、可溶性细胞间黏附分子1(sICAM-1)水平的影响。方法:选取2019年1月至2021年9月北京中西医结合医院收治的86例CP患者,按随机数字表法分为观察组与对照组各43例。对照组患者口服盐酸多西环素片治疗,在此基础上,观察组患者口服人工牛黄甲硝唑胶囊治疗。连续治疗4周后观察两组患者的疗效;比较治疗前后两组患者牙周评估相关指标[附着丧失(AL)、探诊深度(PD)、菌斑指数(PLI)和龈沟出血指数(SBI)]水平,龈沟液和血清中RANKL、MMP-8、NE、sICAM-1水平;统计两组患者不良反应发生情况。结果:观察组患者的总有效率(95.3%,41/43)较对照组(81.4%,35/43)显著提高,差异有统计学意义(P<0.05)。治疗后,两组患者的AL、PD均显著减小,PLI、SBI以及龈沟液和血清中RANKL、MMP-8、NE、sICAM-1水平均显著降低,均以观察组为甚,差异均有统计学意义(P<0.05)。观察组不良反应发生率(14.0%,6/43)与对照组(9.3%,4/43)比较,差异无统计学意义(P>0.05)。结论:应用人工牛黄甲硝唑胶囊联合多西环素治疗CP的总体疗效满意,是改善患者牙周状态的安全有效途径,其作用可能与其显著下调龈沟液和血清中RANKL、MMP-8、NE和sICAM-1的表达水平有关。OBJECTIVE:To probe into the clinical efficacy of Artificial bezoar metronidazole capsules combined with doxycycline in the treatment of chronic periodontitis(CP)and its effects on the levels of Receptor activator of nuclear factor-κB ligand(RANKL),matrix metalloproteinase 8(MMP-8),neutrophil elastase(NE)and soluble intercellular adhesion molecule 1(sICAM-1)in patients’gingival crevicular fluid and serum.METHODS:Totally 86 patients with CP admitted into Beijing Hospital of Integrated Chinese and Western Medicine from Jan.2019 to Sept.2021 were divided into the observation group and control group by random number table method,with 43 cases in each group.The control group was treated with Doxycycline hydrochloride tablets orally,on this basis,the observation group was given Artificial bezoar metronidazole capsules orally.After 4 consecutive weeks of treatment,the efficacy of the two groups were observed;the periodontal assessment related indexes[attachment loss(AL),probing depth(PD),plaque index(PLI),sulcus bleeding index(SBI)],the RANKL,MMP-8,NE and sICAM-1 levels in gingival crevicular fluid and serum were compared between two groups before and after treatment;the incidences of adverse drug reactions of the two groups were collected.RESULTS:The total effective rate of the observation group(95.3%,41/43)was significantly higher than that of the control group(81.4%,35/43),with statistically significant difference(P<0.05).After treatment,AL and PD in two groups were significantly decreased,while PLI,SBI,and the levels of RANKL,MMP-8,NE and sICAM-1 in gingival crevicular fluid and serum were significantly decreased in two groups,especially in observation group,with statistical significance(P<0.05).The incidence of adverse drug reactions of observation group was 14.0%(6/43),the difference was not statistically significant(P>0.05)in comparison with the control group(9.3%,4/43).CONCLUSIONS:The overall efficacy of Artificial bezoar metronidazole capsules combined with doxycycline in the treatment of CP is satisfactory,w

关 键 词：慢性牙周炎 人工牛黄甲硝唑胶囊 多西环素 牙周状况 牙周组织吸收因子 

分 类 号：R978.1[医药卫生—药品]