布地奈德联合沙丁胺醇雾化吸入治疗小儿呼吸阻塞的效果分析  

Analysis of the effect of budesonide combined with salbutamol aerosol inhalation in the treatment of respiratory obstruction in children

作　　者：李霞[1] LI Xia(Department of Pediatrics,Brain Hospital of Liaocheng People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院脑科医院儿科,252000

出　　处：《中国现代药物应用》2023年第6期1-5,共5页Chinese Journal of Modern Drug Application

摘　　要：目的探讨布地奈德联合沙丁胺醇雾化吸入治疗小儿呼吸阻塞的效果。方法84例呼吸阻塞患儿,采用随机数字表法分为对照组和实验组,每组42例。对照组患儿行沙丁胺醇雾化吸入治疗,实验组患儿行沙丁胺醇联合布地奈德雾化吸入治疗。对比两组患儿症状改善时间、治疗效果、不良反应发生情况及治疗前后呼吸功能[呼气峰值流速(PEF)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量的比值(FEV1/FVC)]、生活质量。结果实验组患儿喘息、咳嗽、呼吸困难以及喘鸣音改善时间分别为(4.22±1.21)、(5.88±1.34)、(3.11±1.12)、(4.77±1.36)d,均短于对照组的(5.87±1.42)、(7.62±1.78)、(5.12±1.35)、(6.02±1.42)d,差异具有统计学意义(P<0.05)。治疗后,实验组患儿FEV1/FVC、FEV1、PEF分别为(65.98±1.06)%、(2.41±1.24)L、(2.41±0.36)L/s,高于对照组的(64.77±1.88)%、(1.88±1.01)L、(2.21±0.23)L/s,差异有统计学意义(P<0.05)。实验组患儿治疗总有效率为95.24%,高于对照组的76.19%,差异具有统计学意义(P<0.05)。治疗后,实验组患儿活动受限、哮喘症状、心理状况、对刺激源反应、对自身健康的关心评分分别为(49.87±5.14)、(54.74±5.11)、(21.42±4.12)、(16.45±3.22)、(12.42±1.12)分,均高于对照组的(44.52±3.64)、(52.35±4.12)、(18.32±3.75)、(14.32±2.87)、(10.32±1.75)分,差异具有统计学意义(P<0.05)。实验组患儿不良反应发生率为4.76%,低于对照组的19.05%,差异有统计学意义(P<0.05)。结论呼吸阻塞患儿接受布地奈德联合沙丁胺醇雾化吸入治疗效果显著,安全性更高,有利于患儿呼吸功能的改善,生活质量提高,值得临床推广应用。Objective To discuss the effect of budesonide combined with salbutamol aerosol inhalation in the treatment of respiratory obstruction in children.Methods A total of 84 children with respiratory obstruction were divided into a control group and an experimental group according to the random numerical table,with 42 cases in each group.Children in the control group were treated with salbutamol aerosol inhalation,and children in the experimental group were treated with salbutamol and budesonide aerosol inhalation.Both groups were compared in terms of symptom improvement time,therapeutic effect,occurrence of adverse reactions and respiratory function[peak expiratory flow rate(PEF),forced expiratory volume in one second(FEV1),and FEV1 to forced vital capacity(FEV1/FVC)],and quality of life.Results The improvement time of pant,cough,dyspnea and wheeze in the experimental group were(4.22±1.21),(5.88±1.34),(3.11±1.12)and(4.77±1.36)d,which were shorter than those of(5.87±1.42),(7.62±1.78),(5.12±1.35)and(6.02±1.42)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the FEV1/FVC,FEV1,and PEF in the experimental group were(65.98±1.06)%,(2.41±1.24)L,and(2.41±0.36)L/s,which were higher than those of(64.77±1.88)%,(1.88±1.01)L,and(2.21±0.23)L/s in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the experimental group was 95.24%,which was higher than that of 76.19%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of activity limitation,asthma symptoms,psychological status,reaction to stimulus sources,and concern for their own health in the experimental group were(49.87±5.14),(54.74±5.11),(21.42±4.12),(16.45±3.22),and(12.42±1.12)points,which were higher than those of(44.52±3.64),(52.35±4.12),(18.32±3.75),(14.32±2.87),and(10.32±1.75)points in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse

关 键 词：小儿呼吸阻塞 布地奈德 沙丁胺醇 效果 呼吸功能 生活质量 安全性 

分 类 号：R725.6[医药卫生—儿科]