甘露醇、七叶皂苷钠单用或联合治疗胫腓骨骨折肢体肿胀的临床疗效分析  

Analysis of clinical efficacy of mannitol and sodium aescinate alone or combinedtreatment of limb swelling of tibia and fibula fractures

作　　者：刘健[1] 张昊 刘凯恒 李亚楠 LIU Jian;ZHANG Hao;LIU Kaiheng;LI Yanan(Department of Orthopaedics,the first Hospital of Traditional Chinese Medicine of Baoding,Baoding 071000,China)

机构地区：[1]河北省保定市第一中医院骨科,河北保定071000

出　　处：《长春中医药大学学报》2023年第4期440-443,共4页Journal of Changchun University of Chinese Medicine

基　　金：河北省保定市科技计划项目(2141ZF099)。

摘　　要：目的探讨甘露醇、七叶皂苷钠单用或联合治疗胫腓骨骨折肢体肿胀的效果。方法选择2020年12月-2021年6月本院骨科收治的胫腓骨骨折肢体肿胀患者120例,采用随机数表法分为甘露醇组、七叶皂苷钠组与联合组,各40例。甘露醇组单独给予甘露醇治疗,七叶皂苷钠组单独给予七叶皂苷钠治疗,联合组给予甘露醇联合七叶皂苷钠治疗,比较3组前列腺素E1(PGE1)和前列腺素F2α(PGF2α)水平、临床疗效、肢体肿胀程度、血清炎性因子[C反应蛋白(CRP)、血清肿瘤坏死因子-ɑ(TNF-ɑ)、降钙素原(PCT)]水平及不良反应发生率。结果3组患者PGE1、CRP、TNF-ɑ、PCT水平治疗后较治疗前均降低(P<0.05),且联合组低于甘露醇组及七叶皂苷钠组(P<0.05),PGF2α水平、PGF2α/PGE1治疗后较治疗前升高(P<0.05),且联合组高于甘露醇组及七叶皂苷钠组(P<0.05);3组肿胀程度治疗后均得到改善(P<0.05),联合组肿胀程度比甘露醇组及七叶皂苷钠组改善更明显(P<0.05);甘露醇组总不良反应发生率为15.00%,七叶皂苷钠组总不良反应发生率为17.50%,联合组总不良反应发生率为15.00%,3组比较,差异无统计学意义(P>0.05);联合组总有效率(95.00%,38/40)高于甘露醇组(72.50%,29/40)及七叶皂苷钠组(75.00%,30/40)(P<0.05)。结论甘露醇、七叶皂苷钠联合使用能够降低患者血清炎性因子水平,改善肢体肿胀程度,临床疗效明显且安全性较好。Objective To investigate the effect of mannitol and sodium aescinate alone or combined treatment of limb swelling of tibia and fibula fractures.Methods 120 Patients with limb swelling of tibia and fibula fractures who were admitted to the department of orthopaedics in our hospital from December 2020 to June 2021 were collected and divided into the mannitol group(40 cases),the sodium aescinate group(40 cases)and the combined group(40 cases)according to random number table method,the mannitol group was treated with mannitol alone,the sodium aescinate group was treated with sodium aescinate alone,and the combined group was treated with mannitol combined with sodium aescinate.The levels of prostaglandin E1(PGE1)and prostaglandin F2α(PGF2α),clinical efficacy,limb swelling degree,levels of serum inflammatory factors[C-reactive protein(CRP),serum tumor necrosis factor-α(TNF-α),procalcitonin(PCT)]and incidence of adverse reactions were compared.Results After treatment the levels of PGE1,CRP,TNF-αand PCT in the three groups were lower than those before treatment(P<0.05),and the combined group were lower than the mannitol group and sodium aescinate group(P<0.05),the PGF2αlevel and PGF2α/PGE1 ratio were higher than those before treatment(P<0.05),and the combined group were higher than the mannitol group and sodium aescinate group(P<0.05);the swelling degree of the three groups was improved after treatment(P<0.05),but the swelling degree of the combined group was improved more signifi cantly than the mannitol group and the sodium aescinate group(P<0.05);the total incidence of adverse events was 15.00%,17.50%and 15.00%respectively in the mannitol group,in the sodium aescinate group and in the combined group,and there was no signifi cant difference between the 3 groups(P>0.05);The total effective rate of the combined group(95.00%)was higher than that of the mannitol group(72.50%)and the sodium aescinate group(75.00%)(P<0.05).Conclusion The combined use of mannitol and sodium aescinate can reduce the levels of serum infl

关 键 词：甘露醇 七叶皂苷钠 胫腓骨骨折 肢体肿胀 

分 类 号：R274.1[医药卫生—中医骨伤科学]