载银二氧化硅改性硅橡胶的抗菌性能和生物安全性  

Antibacterial Property and Biosafety of Silicone Rubber Modified with Silver-Loaded Silica

作　　者：侯晓杰 薛宝霞 刘书浩 朱彦霖 牛梅 杨永珍 张利[2,3] Xiaojie Hou;Baoxia Xue;Shuhao Liu;Yanlin Zhu;Mei Niu;Yongzhen Yang;Li Zhang(School of Public Health,Shanxi Medical University,Taiyuan 030001,China;Third Hospital of Shanxi Medical University(Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital),Taiyuan 030032,China;Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030032,China;College of Textile Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,China)

机构地区：[1]山西医科大学公共卫生学院,山西太原030001 [2]山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院),山西太原030032 [3]山西浙大新材料与化工研究院,山西太原030032 [4]太原理工大学轻纺工程学院,山西太原030024 [5]太原理工大学新材料界面科学与工程教育部重点实验室,山西太原030024

出　　处：《高分子材料科学与工程》2023年第2期111-116,共6页Polymer Materials Science & Engineering

基　　金：山西浙大新材料与化工研究院技术开发项目(2021SX-TD013);山西省基础研究计划项目(20210302124200,202103021224355,202203021211065);纳米药物可控缓释省技术创新中心(202104010911026)。

摘　　要：通过硫化法制备了一种载银二氧化硅(SiO2)改性抗菌硅橡胶,并采用抑菌平板法、溶血试验及细胞毒性测试对其抗菌性能及生物安全性等进行表征和分析。结果表明,在载银SiO2抗菌剂含量为20 mg/mL时,硅橡胶对大肠杆菌与金黄色葡萄球菌的抑菌率分别达到100%和66%;溶血试验表明,抗菌硅橡胶的溶血率小于5%;且细胞毒性测试结果显示其细胞毒性为0级,表明载银SiO2改性抗菌硅橡胶具有良好的抗菌性能及生物安全性。在抗菌医用导管领域,表现出广阔的临床应用前景。A kind of antibacterial silicone rubber modified with silver-loaded silica(SiO2)was prepared by vulcanization,and its antibacterial properties and biological safety were characterized and analyzed by antibacterial plate method,hemolysis and cytotoxicity test.The results show that,when the content of silver-loaded SiO2 antibacterial agent is 20 mg/mL,the antibacterial rate of silicone rubber against Escherichia coli and Staphylococcus aureus reaches 100%and 66%,respectively.Hemolysis test show that,the hemolysis rate of antibacterial silicone rubber is less than 5%.And the cytotoxicity of modified silicone rubber is grade 0.These show that silver-loaded SiO2 modified antibacterial silicone rubber has good antibacterial performance and biological safety.In the field of antibacterial medical catheter,this kind of silicone rubber shows broad clinical application prospect.

关 键 词：硅橡胶 抑菌性能 溶血性 细胞毒性 

分 类 号：R318.08[医药卫生—生物医学工程]