黄芪颗粒对支气管肺发育不良患儿白细胞介素-6嗜酸细胞阳离子蛋白及免疫功能的影响  

Effect of Huangqi granule on IL-6,ECP and immune function in children with bronchopulmonary dysplasia

作　　者：齐骥 侯晓 魏丽 陈勤利 张辉 QI Ji;HOU Xiao;WEI Li;CHEN Qin-li;ZHANG Hui(The Second Affiliated Hospital of Shandong First Medical University,Taian,Shandong 271000,China)

机构地区：[1]山东第一医科大学第二附属医院,山东泰安271000

出　　处：《中国妇幼保健》2023年第7期1213-1216,共4页Maternal and Child Health Care of China

基　　金：山东省中医药科技发展计划项目(2017-259)。

摘　　要：目的探讨黄芪颗粒对支气管肺发育不良(BPD)患儿IL-6、ECP及免疫功能的影响。方法选取2017年1月—2020年12月山东第一医科大学第二附属医院收治的BPD患儿60例为研究对象,同时选取同期健康查体婴儿30例为健康对照组,比较两组婴儿血清白细胞介素-6(IL-6)、嗜酸细胞阳离子蛋白(ECP)及T淋巴细胞亚群水平。将60例BPD患儿随机分为两组:黄芪组30例、常规组30例,黄芪组患儿在BPD常规治疗护理基础上,自矫正胎龄3个月龄时给予黄芪颗粒治疗[0.2 g/(kg·次),2次/d,14 d为1个疗程,共使用3个疗程],比较两组患儿治疗前后血清IL-6、ECP及T淋巴细胞亚群水平、体质量身长增长差值及用药后1年内因感染再入院率。结果与同龄健康婴儿比较,BPD组患儿血清IL-6、ECP水平明显增高[(17.5±8.65)pg/ml vs.(9.7±3.09)pg/ml,(30.13±10.18)pg/ml vs.(13.44±5.27)ng/ml]、T淋巴细胞亚群CD3^(+)、CD4^(+)、CD8^(+)、CD4/CD8均明显降低(均P<0.01)。黄芪组患儿在使用黄芪颗粒治疗3个月后,与治疗前和治疗后对照组患儿比较,血清IL-6及ECP水平明显下降[(12.14±4.39)pg/ml vs.(17.80±9.67)pg/ml,(16.96±6.88)pg/ml vs.(17.21±7.65)pg/ml,(19.48±7.35)pg/ml vs.(30.22±10.79)pg/ml,(26.03±10.02)ng/ml vs.(30.35±9.50)pg/ml],T淋巴细胞亚群CD3^(+)、CD4^(+)、CD4/CD8明显增高(均P<0.05),同时患儿体质量增长明显优于常规组,因感染再入院率明显低于常规组[(1.38±0.21)kg vs.(1.26±0.20)kg,11例(36.7%)vs.19例(63.3%),均P<0.05)]。结论黄芪颗粒可以降低BPD患儿的炎症指标,增强其免疫功能,促进其生长发育,减少感染概率。Objective To explore the effect of Huangqi granule on inflammatory response and immune function in children with bronchopulmonary dysplasia(BPD).Methods 60 children with BPD were selected as the research objects,and 30 healthy infants in the same period were selected as the control group.The levels of serum interleukin-6(IL-6),eosinophil cationic protein(ECP)and T lymphocyte subsets were compared between the two groups.60 children with BPD were randomly divided into two groups:30 cases in the Huangqi group and 30 cases in the routine group.On the basis of routine treatment and nursing of BPD,children in the Huangqi group were treated with Huangqi granule(0.2 g/kg/time,2 times per day,14 days as a course of treatment,a total of three courses).The levels of serum IL-6,ECP and T lymphocyte subsets,the difference of body weight and length growth and the rate of re-hospitalization due to infection within 1 year after treatment were compared between the two groups.Results Compared with healthy infants of the same age,children in BPD group had low immune function and persistent inflammatory reaction.The levels of serum IL-6 and ECP were increased significantly[(17.5±8.65)pg/ml vs.(9.7±3.09)pg/ml,(30.13±10.18)pg/ml vs.(13.44±5.27)ng/ml],and the T lymphocyte subsets CD3^(+),CD4^(+),CD8^(+)and CD4/CD8 were decreased significantly(P<0.01).After 3 months of treatment with Huangqi granule,compared with before treatment and the routine group after treatment,the levels of serum IL-6 and ECP were decreased significantly[(12.14±4.39)pg/ml vs.(17.80±9.67)pg/ml,(16.96±6.88)pg/ml vs.(17.21±7.65)pg/ml,(19.48±7.35)pg/ml vs.(30.22±10.79)pg/ml,(26.03±10.02)ng/ml vs.(30.35±9.50)pg/ml],and the T lymphocyte subsets CD3^(+),CD4^(+),CD4/CD8 were increased significantly.And the weight growth of children in Astragalus group was significantly better than that in the routine group,and the readmission rate due to infection was significantly lower than that in the routine group[(1.38±0.21)kg vs.(1.26±0.20)kg,11 case(36.7%)vs.19 case(

关 键 词：黄芪颗粒 支气管肺发育不良 白细胞介素-6 嗜酸细胞阳离子蛋白 T淋巴细胞亚群 

分 类 号：R725.56[医药卫生—儿科]