黄芪化学成分和药理作用及Q-marker预测分析  

Chemical constituents and pharmacological effects of Astragali Radix and predictive analysis on quality markers

作　　者：张柂儇 刘海龙 王瑞琼[1,2] 马倩倩 房敏 李泉洋 吴国泰 ZHANG Yi-xuan;LIU Hai-long;WANG Rui-qiong;MA Qian-qian;FANG Min;LI Quan-yang;WU Cuo-tai(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Province Traditional Chinese Medicine Modern Pharmaceutical Engineering Research Institute Co.,Ltd.,Lanzhou 730010,China;Gansu Province Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中药现代制药工程研究院有限公司,兰州730010 [3]甘肃省中药药理与毒理学重点实验室,兰州730000

出　　处：《中国新药杂志》2023年第4期410-419,共10页Chinese Journal of New Drugs

基　　金：甘肃省教育厅双一流学科建设重点科研项目(GSSYLXM-05);甘肃省2019年重点人才项目(2019-039)。

摘　　要：黄芪是蒙古黄芪[Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao]和膜荚黄芪[Astragalus membranaceus(Fisch.)Bge.]的干燥根,为甘肃大宗药材,其主要化学成分有多糖、黄酮、皂苷、生物碱、氨基酸、微量元素及有机酸等。其药理作用主要集中在提高免疫力、抗氧化、抗肿瘤、保护心血管、促进机体代谢、降血糖、利尿消肿等方面。本文通过文献检索,对黄芪资源分布、化学成分和药理作用进行梳理总结,围绕传统药性、功效、化学成分和不同配伍等方面对黄芪质量标志物(quality marker,Q-Marker)进行了预测分析,最终预测了黄芪多糖、芒柄花苷、毛蕊异黄酮、芒柄花素、黄芪皂苷Ⅰ和Ⅱ、黄芪甲苷等中药成分,为黄芪质量控制提供科学依据。Huangqi(Astragali Radix)is the dry root of Mongol Milkvetch(Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao)and Membranous Milkvetch(Astragalus membranaceus(Fisch.)Bge.),which is a major medicinal material in Gansu Province.It mainly contains Astragali Radix polysaccharides,flavonoids,saponins,alkaloids,amino acids,trace elements,organic acids and other chemical components.The pharmacological effects of Huangqi mainly focus on improving immunity,anti-oxidation,anti-tumor,protecting cardiovascular,promoting body metabolism,lowering blood sugar,diuresis and decreasing swelling.Based on literature retrieval,the distribution of resources,chemical components and pharmacological effects of Astragalus are reviewed and summarized.The quality markers(Q-Marker)of Astragali Radix are predicted based on traditional medicinal properties,efficacy,chemical components and different compatibility.The chemical components of Astragali Radix polysaccharide,ononin,calycosin,formononetin,astragalosideⅠ,astragalosideⅡ,and astragalosideⅣwere predicted by the analysis,providing a scientific basis for the quality control of Astragali Radix.

关 键 词：黄芪 质量标志物 化学成分 药理作用 免疫调节 

分 类 号：R962[医药卫生—药理学] R282.71[医药卫生—药学]