基于数据挖掘的明清医家失眠医案用药规律研究  

Study on the Medication Law for Insomnia Medical Cases of Ming and Qing Dynasties based Data Mining

作　　者：张奇 张雪娟 ZHANG Qi;ZHANG Xunjuan(Beijing He Ping Li Hospital,Beijing 100010,China)

机构地区：[1]北京市和平里医院,北京100013

出　　处：《世界睡眠医学杂志》2023年第1期35-38,共4页World Journal of Sleep Medicine

摘　　要：目的:基于数据挖掘探讨明清医家治疗失眠医案的用药规律。方法:检索《中华医典》数据库中有关治疗失眠的明清医家医案,提取医案处方中用药信息,建立数据库,统计药物分类、性味和归经,对高频药物进行聚类和关联规则分析。结果:共纳入治疗失眠医案490例次,涉及方剂490首,药物326味。使用频次前5位的药物分别为茯神(177次)、茯苓(169次)、半夏(166次)、酸枣仁(163次)、甘草(150次);使用频次前5位的药物分类分别为安神类(699次)、化痰类(624次)、清热类(527次)、健脾类(522次)、补阴类(461次);药性以寒性(1916次)和温性(1594次)为主,药味以甘味(3062)、苦味(1905次)、辛味(1374次)为主。对使用频次>49次的24种高频药物进行聚类分析,得到5类核心药物聚类组;关联规则分析,得9条药对及药组关联规则。结论:明清医家治疗失眠用药以安神、化痰、清热、健脾、补阴等为主。临床选药应虚实兼顾,五脏并重。Objective:To explore the rule of medication for treating insomnia medical cases in Ming and Qing Dynasty.Methods:The insomnia cases were collected that were in Ming and Qing dynasty medical records.The Traditional Chinese medicine database of insomnia prescription was established.The drug classification and efficacy,property,taste and channel tropism were counted.The cluster analysis and association rule mining were performed for the high frequency drugs.Results:Totally 490 cases of insomnia were included,involving 490 prescriptions and 326 herbs.The former 5 herbs used were Fushen(Poria cum ligno hospite,177),Fuling(Poria,169),Banxia(Rhizoma Pinelliae,166),Suanzaoren(Semen Zizyphi Spinosae,163)and Gancao(Radix Glycyrrhizae,150).The top 5 drugs used were soothe the nerves(699),reduce phlegmclassified(624),clearing heat(527),invigorating spleen(522)and nourishing Yin(461).The herbs were mainly cold(1916)and warm(1594)in property,and the taste were mainly sweet(3062),bitter(1905),and pungent(1374).Cluster analysis was performed on 24 high-frequency drugs with frequency larger than 49,and 5 groups of core drug clusters were obtained.Through association rules analysis was performed on 24 high-frequency drugs,a total of 9 drug pairs and drug group association rules were obtained.Conclusion:In the Ming and Qing Dynasties,the treatment of insomnia was mainly for soothe the nerves,dissolving phlegm,clearing heat,invigorating spleen and replenishing the deficient.It should be giving consideration to excess and deficiency,and take account of the five zang organs.

关 键 词：失眠 明清医案 数据挖掘 用药规律 

分 类 号：R338.63[医药卫生—人体生理学]