清热解毒口服液治疗急性上呼吸道感染的疗效和对患者睡眠质量的影响  

Efficacy of Qingrejiedu Oral liquid in the Treatment of Acute Upper Respiratory Tract Infection and the Effect on Sleep Quality of Patients

作　　者：王海霞[1] WANG Haixia(Health Department of the Third People′s Hospital of Ji′nan,Ji′nan 250132,China)

机构地区：[1]济南市第三人民医院保健科,济南250132

出　　处：《世界睡眠医学杂志》2023年第1期39-41,44,共4页World Journal of Sleep Medicine

摘　　要：目的:探究清热解毒口服液对急性上呼吸道感染患者的临床疗效及对睡眠质量的影响。方法:选取2021年11月至2022年4月济南市第三人民医院保健科收治的急性上呼吸道感染患者130例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组65例。2组患者均给予常规抗感染治疗,观察组在此基础上联合清热解毒口服液治疗。统计2组患者临床有效率、症状时间指标、治疗前后炎症介质因子、免疫因子水平以及睡眠质量。结果:治疗后,观察组总有效率为92.3%,显著高于对照组的81.5%;观察组患者的起效时间、咳嗽消失时间和退热时间均明显短于对照组;2组患者白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平较治疗前均显著下降,且观察组IL-6、TNF-α水平均显著低于对照组;2组患者CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平较治疗前均显著改善,且观察组上述指标水平均显著优于对照组;2组患者匹兹堡睡眠质量指数(PSQI)评分均显著降低,且观察组PSQI评分明显低于对照组,2组以上指标比较,差异均有统计学意义(均P<0.05)。结论:清热解毒口服液能够显著降低急性上呼吸道感染患者炎性因子水平,提高机体免疫力,改善睡眠质量,促进疾病恢复,提高疗效,具有良好的临床应用价值。Objective:To investigate the effect of Qingrejiedu oral liquid on the clinical efficacy and sleep quality of patients with acute upper respiratory tract infection.Methods:A total of 130 patients with acute upper respiratory tract infection admitted to Health Department of the Third People′s Hospital of Ji′nan from November 2021 to April 2022 were selected as the research objects,and they were divided into a control group and an observation group according to the number table method,with 65 cases in each group.Both groups were given conventional anti-infective therapy,and the observation group was combined with Qingrejiedu oral liquid on this basis.The clinical effective rate,symptom time index,inflammatory mediator factor before and after treatment,immune factor level and sleep quality were counted in the two groups of patients.Results:After treatment,the total effective rate in the observation group was 92.3%,which was significantly higher than 81.5%in the control group;the onset time,cough disappearance time and fever reduction time of the observation group were significantly shorter than those of the control group;The levels of IL-6 and TNF-αwere significantly decreased compared with those before treatment,and the levels of IL-6 and TNF-αin the observation group were significantly lower than those in the control group;the levels of CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in both groups were significantly improved compared with those before treatment and the above indexes in the observation group were significantly better than those in the control group;the PSQI scores of the two groups were significantly decreased,and the PSQI scores of the observation group were significantly lower than those of the control group,with statistical significance(P<0.05).Conclusion:Qingrejiedu oral liquid can significantly reduce the level of inflammatory factors in patients with acute upper respiratory tract infection,improve immunity,improve sleep quality,promote disease recovery,and improve efficacy,which has good clinical ref

关 键 词：急性上呼吸道感染 清热解毒口服液 炎症介质 免疫因子 睡眠质量 

分 类 号：R562[医药卫生—呼吸系统]