Ironing out macrophages in atherosclerosis  

作　　者：Lei Wang Jing Cai Tong Qiao Kuanyu Li 

机构地区：[1]Department of Vascular Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China [2]Jiangsu Key Laboratory of Molecular Medicine,Medical School of Nanjing University,Nanjing 210093,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第1期1-10,共10页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(Nos.81870348 and 31871201)。

摘　　要：The most common cause of death worldwide is atherosclerosis and related cardiovascular disorders.Macrophages are important players in the pathogenesis of atherosclerosis and perform critical functions in iron homeostasis due to recycling iron by phagocytosis of senescent red blood cells and regulating iron availability in the tissue microenvironment.With the growth of research on the“iron hypothesis”of atherosclerosis,macrophage iron has gradually become a hotspot in the refined iron hypothesis.Macrophages with the M1,M2,M(Hb),Mox,and other phenotypes have been defined with different iron-handling capabilities related to the immune function and immunometabolism of macrophages,which influence the progression of atherosclerosis.In this review,we focus on macrophage iron and its effects on the development of atherosclerosis.We also cover the contradictory discoveries and propose a possible explanation.Finally,pharmaceutical modulation of macrophage iron is discussed as a promising target for atherosclerosis therapy.

关 键 词：METABOLISM EXPLANATION refined 

分 类 号：R54[医药卫生—心血管疾病]