老年急性冠状动脉综合征患者贫血对预后影响的系统评价  

Anemia on the prognosis of elderly patients with acute coronary syndrome:a meta-analysis

作　　者：樊楚 黄觊[1] 闫航语 李丹 李志忠[1] 程宇彤[1] 李昭[1] 李南[1] Fan Chu;Huang Ji;Yan Hangyu;Li Dan;Li Zhizhong;Cheng Yutong;Li Zhao;Li Nan(Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院心内科十五病房,100029

出　　处：《中华老年医学杂志》2023年第4期458-462,共5页Chinese Journal of Geriatrics

基　　金：北京市属医院科研培育计划项目(PZ2020005)。

摘　　要：目的探讨老年急性冠状动脉(冠脉)综合征患者贫血对预后的影响。方法检索PubMed、Scopus、OVID、Cochrane library、Web of Science、Embase、中国知网、中国生物医学、万方、维普数据库中关于贫血与老年急性冠脉综合征预后影响的相关研究。检索时限为建库至2022年12月10日,由两名评审员按文献的纳入和排除标准独立完成文献筛选及数据提取,采用Stata 16.0软件进行统计分析。结果在最初检索的1399篇文献中,13篇9540例患者符合纳入标准,平均年龄70.3岁,合并贫血2872例(30.1%),非贫血患者6668例。老年急性冠脉综合征贫血与非贫血患者比较,贫血增加患者的死亡风险(RR=2.28,95%CI:1.74~3.00),同时亦增加缺血(RR=1.36,95%CI:1.13~1.64)和出血事件(RR=2.18,95%CI:1.59~3.01)的发生风险(均P<0.05)。结论贫血增加老年急性冠脉综合征患者死亡风险,与不良预后相关。Objective To examine the effect of anemia on the prognosis of elderly patients with acute coronary syndrome.Methods We searched PubMed,Scopus,OVID,the Cochrane Library,Web of Science,Embase,China National Knowledge Infrastructure,China Biology Medicine Disc,the WanFang and Weipu databases for studies on the association between anemia and the prognosis of acute coronary syndrome in elderly patients.The date range included the period from the establishment of the database to December 10,2022.Two reviewers independently completed the literature screening and data extraction according to the inclusion and exclusion criteria for the literature.Stata 16.0 software was used to analyze the data.Results Of 1399 references retrieved from the initial search,13 met the inclusion criteria,including a total of 9540 patients with a mean age of 70.3 years.2872 of these patients had concurrent anemia and 6668 patients had no anemia.In elderly patients with acute coronary syndrome,those with anemia showed significantly increased risk of death,compared with those with no anemia(RR=2.28,95%CI:1.74-3.00).Anemia also increased the incidence of ischemia(RR=1.36,95%CI:1.13-1.64)and bleeding events(RR=2.18,95%CI:1.59-3.01)(P<0.05 for all).Conclusions Anemia significantly increases the risk of death and is associated with poor prognosis in elderly patients with acute coronary syndrome.

关 键 词：冠状动脉疾病 贫血 预后 系统评价 

分 类 号：R541.4[医药卫生—心血管疾病] R556[医药卫生—内科学]