黄连提取物抗阿尔茨海默病的研究进展  

Research progress on the use of Rhizoma coptidis extract against Alzheimer's disease

作　　者：杨丽洁 姚朝辉[1] Yang Lijie;Yao Zhaohui(Department of Geriatrics,People's Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院老年病科,武汉430060

出　　处：《中华老年医学杂志》2023年第4期467-471,共5页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(82271214)。

摘　　要：黄连提取物具有多种药理活性,包括改善阿尔茨海默病(AD)的认知障碍,其抗AD的主要机制为减少β-淀粉样蛋白(Aβ)的产生、抑制Tau蛋白磷酸化、抑制胆碱酯酶、抗炎、抗氧化、改善细胞凋亡等。本文对黄连提取物的抗AD作用及具体机制进行综述,为相关研究和临床应用提供理论依据。Rhizoma coptidis extract has a variety of pharmacological activities,including alleviating cognitive impairment in Alzheimer's disease(AD).The main mechanisms of its anti-AD activity include reducing the production of amyloid β(Aβ),inhibiting the phosphorylation of Tau protein,inhibiting cholinesterase,anti-inflammation,anti-oxidation,improving apoptosis,etc.This paper reviewed the anti-AD effect of Rhizoma coptidis extract and the specific mechanisms,aiming to provide a theoretical basis for relevant research and clinical practice.

关 键 词：阿尔茨海默病 黄连提取物 小檗碱 淀粉样Β蛋白 TAU蛋白 

分 类 号：R285[医药卫生—中药学]