线粒体DNA拷贝数与女性不孕症的关联性及其机制的研究进展  

Research progress on the relationship between mitochondrial DNA copy number and female infertility and its mechanism

作　　者：董衡蓓 马延敏[1] DONG Hengbei;MA Yanmin(Department of Human Reproductive Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院生殖医学科,北京100026

出　　处：《中国优生与遗传杂志》2023年第3期655-659,共5页Chinese Journal of Birth Health & Heredity

基　　金：北京市医院管理中心临床医学发展专项经费资助(XMLX202122)。

摘　　要：线粒体DNA(mtDNA)拷贝数可以体现线粒体功能,作为线粒体功能的生物标志物与多种疾病相关。目前对mtDNA拷贝数与女性不孕症相关性的研究表明卵母细胞及胚胎细胞mtDNA拷贝数与胚胎质量相关,同时颗粒细胞mtDNA拷贝数也可提示卵母细胞质量。探讨外周血mtDNA拷贝数与女性不孕症的关联逐渐成为研究热点。本文综述mtDNA拷贝数的影响因素及其与女性不孕症的关联,为进一步研究mtDNA拷贝数对女性不孕症的影响提供新的研究方向。Mitochondrial DNA(mtDNA)copy numbers can reflect mitochondrial function.As a biomarker of mitochondrial function,it has been associated with a variety of diseases.The current study of the correlation between mtDNA copy number and female infertility has shown that oocyte and embryo mtDNA copy number are related to embryo quality.At the same time,the copy number of granule cell mtDNA can also indicate oocyte mass.Exploring the association of peripheral blood mtDNA copy number with female infertility has gradually become a research hotspot.In this review,the influencing factors of mtDNA copy number and its association with female infertility provide a new research direction for further research on the effect of mtDNA copy number on female infertility.

关 键 词：生物标志物 线粒体DNA拷贝数 生殖 女性不孕症 

分 类 号：R711.6[医药卫生—妇产科学]