Atypical pituitary hormone–target tissue axis  

作　　者：Chao Xu Zhao He Yongfeng Song Shanshan Shao Guang Yang Jiajun Zhao 

机构地区：[1]Department of Endocrinology and Metabolism,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China [2]Department of Endocrinology and Metabolism,Shandong Provincial Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250021,China [3]Beijing Institute of Tropical Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China

出　　处：《Frontiers of Medicine》2023年第1期1-17,共17页医学前沿（英文版）

摘　　要：A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glands to actuate their manifold functions.However,a number of studies have shown that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs.Each pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in these non-classical target organs.Herein,the extra biological functions of pituitary hormones,thyroid-stimulating hormone,follicle-stimulating hormone,luteinizing hormone,adrenocorticotrophic hormone,and prolactin when they act on non-classical organs were summarized,defined by the novel concept of an“atypical pituitary hormone–target tissue axis.”This novel proposal explains the pathomechanisms of abnormal glucose and lipid metabolism,obesity,hypertension,fatty liver,and atherosclerosis while offering a more comprehensive and systematic insights into the coordinated regulation of environmental factors,genetic factors,and neuroendocrine hormones on human biological functions.The continued exploration of the physiology of the“atypical pituitary hormone–target tissue axis”could enable the identification of novel therapeutic targets for metabolic diseases.

关 键 词：thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone PROLACTIN 

分 类 号：R586[医药卫生—内分泌]