J-shaped association between dietary zinc intake and new-onset hypertension:a nationwide cohort study in China  

作　　者：Panpan He Huan Li Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Chun Zhou Ziliang Ye Qimeng Wu Min Liang Jianping Jiang Guobao Wang Jing Nie Fan Fan Hou Chengzhang Liu Xianhui Qin 

机构地区：[1]Division of Nephrology,Nanfang Hospital,Southern Medical University,National Clinical Research Center for Kidney Disease,State Key Laboratory of Organ Failure Research,Guangdong Provincial Institute of Nephrology,Guangdong Provincial Key Laboratory of Renal Failure Research,Guangdong Provincial Clinical Research Center for Kidney Disease,Guangzhou Regenerative Medicine and Health Guangdong Laboratory,Guangzhou 510515,China [2]Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032,China [3]Institute of Biomedicine,Anhui Medical University,Hefei 230032,China

出　　处：《Frontiers of Medicine》2023年第1期156-164,共9页医学前沿（英文版）

基　　金：the National Institute for Nutrition and Health,China Center for Disease Control and Prevention,Carolina Population Center(P2C HD050924 and T32 HD007168);the University of North Carolina at Chapel Hill,the National Institutes of Health(NIH;R01-HD30880,DK056350,R24 HD050924,and R01-HD38700);the NIH Fogarty International Center(D43 TW009077 and D43 TW007709)for financial support for the CHNS data collection and analysis files from 1989 to 2015 and future surveys,and the China-Japan Friendship Hospital,Ministry of Health for support for CHNS 2009,Chinese National Human Genome Center at Shanghai since 2009,and Beijing Municipal Center for Disease Prevention and Control since 2011;The study was supported by the National Key Research and Development Program(Nos.2022YFC2009600 and 2022YFC2009605);the National Natural Science Foundation of China(Nos.81973133 and 81730019).

摘　　要：We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults.A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included.Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory.Participants with systolic blood pressure≥140 mmHg or diastolic blood pressure≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension.During a median follow-up duration of 6.1 years,4269 participants developed new-onset hypertension.Overall,the association between dietary zinc intake and new-onset hypertension followed a J-shape(P for non-linearity<0.001).The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake(per mg/day:hazard ratio(HR)0.93;95%confidence interval(CI)0.88–0.98)in participants with zinc intake<10.9 mg/day,and increased with the increment of zinc intake(per mg/day:HR 1.14;95%CI 1.11–1.16)in participants with zinc intake≥10.9 mg/day.In conclusion,there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults,with an inflection point at about 10.9 mg/day.

关 键 词：dietary zinc intake new-onset hypertension general population CHNS 

分 类 号：R544.1[医药卫生—心血管疾病]