血清BNP、Gal-3联合左房容积指数对非体外循环冠状动脉搭桥术患者术后新发房颤的预测效能分析  

Predictive Efficacy of Serum BNP,Gal-3 Combined with Left Atrial Volume Index in Patients with Postoperative New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting

作　　者：杨阳 王雪[1] 李晨陆 胡佳文 卢子望 YANG Yang;WANG Xue;LI Chen-lu;HU Jia-wen;LU Zi-wang(Department of Cardiovascular Surgery,The First Affliated Hospital of Xian Jiaotong University Medical College,Xi'an,Shaanxi,710061,China;Department of Internal Medicine-Cardiovascular,Baoji People's Hospital,Baoji,Shaanxi,721000,China)

机构地区：[1]西安交通大学医学院第一附属医院心血管外科,陕西西安710061 [2]宝鸡市人民医院心血管内科,陕西宝鸡721000

出　　处：《现代生物医学进展》2023年第4期692-697,共6页Progress in Modern Biomedicine

基　　金：陕西省科技厅重点研发计划项目(2021SF-149)。

摘　　要：目的:探讨血清B型脑钠肽(BNP)、半乳糖凝集素-3(Gal-3)联合左房容积指数(LAⅥ)对非体外循环冠状动脉搭桥术(OPCAB)患者术后新发房颤的预测效能。方法:选择2020年1月至2022年1月我院心血管外科收治的196例拟行OPCAB患者,根据术后住院期间是否新发房颤将患者分为新发房颤组(36例)和非新发房颤组(160例)。检测两组血清BNP、Gal-3水平和LAⅥ,收集所有患者的临床资料。采用多因素Logistic回归分析OPCAB患者术后新发房颤的影响因素。受试者工作特征(ROC)曲线分析BNP、Gal-3及LAⅥ预测OPCAB患者术后新发房颤的效能。结果:新发房颤组血清BNP、Gal-3水平及LAⅥ高于非新发房颤组(P<0.05)。术后IABP辅助、年龄偏大、高水平BNP、高水平Gal-3、高LAⅥ是OPCAB患者术后新发房颤的危险因素(P<0.05)。联合BNP、Gal-3和LAⅥ预测OPCAB患者术后新发房颤的曲线下面积为0.872,高于BNP、Gal-3、LAⅥ单独检测的0.773、0.711、0.766。结论:OPCAB术后新发房颤患者血清BNP、Gal-3水平和LAⅥ均升高,上述指标均可辅助性预测OPCAB患者术后新发房颤的风险,且联合检测的预测效能更高。Objective:To investigate the predictive efficacy of serum B-type brain natriuretic peptide(BNP),galectin-3(Gal-3)combined with left atrial volume index(LAVI)in patients with postoperative new-onset atrial fibrillation after off-pump coronary artery bypass grafting(OPCAB).Methods:196 patients who were admitted to the Department of Cardiovascular Surgery of our hospital from January 2020 to January 2022 were selected,and they were divided into new-onset atrial fibrillation group(36 cases)and non-new-onset atrial fibrllation group(160 cases)according to whether they had new atrial fibrillation during the postoperative hospital stay.The serum BNP,Gal-3 levels and LAVI in the two groups were detected,and the clinical data of all patients were collected.Multivariate Logistic regression was used to analyze the influencing factors of postoperative new-onset atrial fibrillation in patients with OPCAB.The receiver operating characteristic(ROC)curve was used to analyze the efficacy of BNP,Gal-3 and LAVI in predicting postoperative new-onset atrial fibrillation in patients with OPCAB.Results:The serum BNP,Gal-3 levels and LAVI in the new-onset atrial fibrillation group were higher than those in the non-new-onset atrial fibrillation group(P<0.05).Postoperative IABP assistance,older age,high level of BNP,high level of Gal-3,and high LAVI were risk factors for postoperative new-onset atrial fibrillation in patients with OPCAB(P<0.05).The area under curve of BNP,Gal-3 and LAVI in predicting postoperative new-onset atrial fibrllation in patients with OPCAB was 0.872,which was higher than 0.773,0.711 and 0.766 for BNP,Gal-3 and LAVI alone.Conclusions:The serum BNP,Gal-3 levels and LAVI in patients with new-onset atrial fibrillation after OPCAB are increased,All the above indicators can assist in predicting the risk of new-onset atrial fibrillation in patients with OPCAB after OPCAB,and the combined detection has higher predictive efficiency.

关 键 词：B型脑钠肽 半乳糖凝集素-3 左房容积指数 非体外循环冠状动脉搭桥术 房颤 预测价值 

分 类 号：R541.4[医药卫生—心血管疾病] R541.75[医药卫生—内科学]