血清胰岛素样生长因子结合蛋白3、血清N端骨钙素、25羟基维生素D在骨质疏松检测价值分析  

The Value of Serum Insulin-like Growth Factor Binding Protein 3,Serum N-terminal Osteocalcin and 25 Hydroxyvitamin D in The Detection of Psteoporosis

作　　者：张力[1] 申鸿[2] 郭洁[1] 雷珂[3] 安哲[3] 崔张珂 李林 ZHANG Li;SHEN Hong;GUO Jie;LEI Ke;AN Zhe;CUI Zhang-ke;LI Lin(Department of clinical lab,The Third Affiliated Hospital of Xi'an Medical College,Xian,Shaanxi,710068,China;Department of clinical lab,Xian Jiaotong University Hospital,Xian,Shaanxi,710061,China;Department of clinical lab,The Second Affliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710004,China;Department of clinical lab,Shaanxi Cancer Hospital,Xi'an,Shaanxi,710068,China)

机构地区：[1]西安医学院第三附属医院检验科,陕西西安710068 [2]西安交通大学医院检验科,陕西西安710061 [3]西安交通大学第二附属医院检验科,陕西西安710004 [4]陕西省肿瘤医院检验科,陕西西安710068

出　　处：《现代生物医学进展》2023年第5期914-917,926,共5页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(2020SF-170)。

摘　　要：目的:研究骨质疏松患者行血清胰岛素样生长因子结合蛋白3(IGFBP-3)、血清N端骨钙素(N-MID)、25羟基维生素D[25(OH)D]、骨密度(BMD)检测的效果。方法:数据取自本院2021年4月-2022年5月收治的80例骨质疏松患者,均行IGFBP-3、N-MID及25(OH)D检测,分析检测结果。结果:实验组患者的IGFBP-3、25(OH)D及N-MID、BMD水平均低于参照组患者相应指标水平(P<0.05);实验组患者IGFBP-3、25(OH)D及N-MID、BMD变化水平相互为正相关关系(P<0.05);采用多元回归分析显示影响BMD的主要因素中,IGFBP-3、25(OH)D、N-MID均为骨质疏松保护因素。结论:骨质疏松患者行IGFBP-3、25(OH)D及N-MID检测可切实观察病情、为疾病治疗提供参考数据,利于改善预后、效果显著。Objective:To study the serum insulin-like growth factor-binding protein 3(IGFBP-3),serum N-terminal osteocalcin(N-MID),25-hydroxyvitamin D(25(OH)D),bone mineral density in osteoporosis patients(BMD)detection effect.Methods:Data were collected from 80 patients with osteoporosis who were admitted to our hospital from April 2021 to May 2022.Results:The levels of IGFBP-3,25(OH)D,N-MID,and BMD in the research group were lower than those in the reference group(P<0.05).25(OH)D,N-MID,and BMD levels were positively correlated with each other(P<0.05).Multiple regression analysis showed that among the main factors affecting BMD,IGFBP-3,25(OH)D and N-MID are both protective factors for osteoporosis.Conclusion:The detection of IGFBP-3,25(OH)D and N-MID in patients with osteoporosis can effectively observe the disease and provide reference data for disease treatment,which is beneficial to improve the prognosis and has a significant effect.

关 键 词：血清胰岛素样生长因子结合蛋白3 血清N端骨钙素 25羟基维生素D 骨质疏松 

分 类 号：R68[医药卫生—骨科学] R446.11[医药卫生—外科学]