血管内超声评价川崎病晚期患儿颈动脉功能、颈动脉内膜-中膜厚度和组织特征的临床研究  

Clinical study of Carotid Artery Function,Intima-media Thickness and Tissue Characteristics Evaluated by Intravascular Ultrasound in Children with Advanced Kawasaki Disease

作　　者：李倩 贾红娥[2] 孙杰 牟孙凡 王媛 LI Qian;JIA Hong-e;SUN Jie;MOU Sun-fan;WANG Yuan(Medical Ultrasound Center,Northwest Women's and Children's Hospital,Xian,Shaanxi,710061,China;Department ofUltrasound Medicine,Affiliated Hospital of Yan'an University,Yan'an,Shaanxi,716000,China)

机构地区：[1]西北妇女儿童医院医学超声中心,陕西西安710061 [2]延安大学附属医院超声医学科,陕西延安716000

出　　处：《现代生物医学进展》2023年第5期931-935,978,共6页Progress in Modern Biomedicine

基　　金：陕西省科技厅一般项目(2020SF-237)。

摘　　要：目的:探究血管内超声评价川崎病晚期患儿颈动脉功能、颈动脉内膜-中膜厚度和组织特征的临床价值。方法:选取81例川崎病晚期患儿作为本研究的川崎病组,同时选择同一时期的81例健康体检者作为本研究的对照组。所有受试者均通过血管内超声检查,对比分析两组一般临床资料、颈动脉功能、颈动脉内膜-中膜厚度、组织特征、颈动脉血流动力学和血管内皮功能。结果:川崎病组和对照组儿童的一般临床资料比较,差异均无统计学意义(P>0.05)。川崎病组患儿颈动脉血管僵硬度、脉搏波传导速度、颈动脉内膜-中膜厚度、血管的压力-应变弹性系数、硬度指数、颈动脉阻力指数和颈动脉僵硬度均显著高于对照组,而血管顺应性、血管径向应变率、动脉最大剪切率、颈动脉最小剪切率、颈动脉搏动指数和血管内皮依赖性舒张功能则显著小于对照组(P<0.05)。结论:血管内超声可有效评价川崎病晚期患儿颈动脉功能、颈动脉内膜-中膜厚度和组织特征,能够为后续疾病的治疗及预后提供重要参考,值得推广使用。Objective:To explore the clinical value of intravascular ultrasound in evaluating carotid artery function,carotid intima-media thickness and tissue characteristics in children with advanced Kawasaki disease.Methods:Eighty-one children with advanced kawasaki disease were selected as the kawasaki disease group,and eighty-one healthy subjects during the same period were selected as the control group.All subjects underwent intravascular ultrasound examination,and the general clinical data,carotid artery function,carotid intima-media thickness,tissue characteristics,carotid hemodynamics and vascular endothelial function were compared and analyzed between the two groups.Results:There was no significant difference in general clinical data between kawasaki disease group and control group(P>0.05).Carotid artery stiffness,pulse wave conduction velocity,carotid intima-media thickness,pressure strain elasticity coefficient,hardness index,carotid resistance index and carotid artery stiffness in kawasaki disease group were significantly higher than those in control group.Vascular compliance,radial strain rate,maximum artery shear rate,minimum carotid artery shear rate,carotid pulse index and endothelium-dependent vasodilation were significantly lower than those in the control group(P<0.05).Conclusion:Intravascular ultrasound can effectively evaluate the carotid artery function,carotid intima-media thickness and tissue characteristics of children with advanced Kawasaki disease,which can provide important reference for the treatment and prognosis of subsequent diseases,and is worthy of popularization.

关 键 词：血管内超声 川崎病晚期患儿 颈动脉功能 颈动脉内膜-中膜厚度 组织特征 临床价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R726.2[医药卫生—诊断学]