腰腿痛贴膏联合温针对关节型银屑病患者中医症候评分、Th17细胞因子及生活质量的影响  

Effect of Yaotuitong Plaster combined with warm needling on TCM symptom scores,Th17 cytokines,and quality of life of patients with psoriatic arthritis

作　　者：刘燕婷 吴迪 王占琴 武辉 LIU Yan-ting;WU Di;WANG Zhan-qin;WU Hui(Department of Dermatology,Shaanxi Provincial Hospital of Chinese Medicine,Xi'an 710003,Shaanxi,CHINA)

机构地区：[1]陕西省中医医院皮肤科,陕西西安710003

出　　处：《海南医学》2023年第7期933-937,共5页Hainan Medical Journal

基　　金：陕西省重点产业创新链项目(编号:2019ZDLSF04-08)。

摘　　要：目的探讨腰腿痛贴膏联合温针对关节型银屑病(PA)患者中医症候评分、Th17细胞因子及生活质量的影响。方法选择2020年5月至2021年5月期间陕西省中医医院收治的PA患者76例,按照随机数表法分为温针组和联合组各38例,温针组采用温针疗法,1次/d,10次为一个疗程,2个疗程间隔3 d,联合组在温针组基础上联用腰腿痛贴膏,1次/3 d,均治疗3个月,比较两组患者治疗后的疗效,治疗前后的中医症候评分、Th17细胞因子、生活质量及不良反应发生情况,疗效以中医症候评分减分率评价,Th17细胞因子使用ELISA法检测,生活质量采用皮肤生活质量指数(DLQI)和简明健康调查问卷(SF-36)评估。结果联合组患者的治疗总有效率为89.47%,明显高于温针组的71.05%,差异有统计学意义(P<0.05);治疗后,两组患者的中医证候积分较治疗前降低,且联合组明显低于温针组,差异均有统计学意义(P<0.05);治疗后,两组患者的Th17细胞因子较治疗前降低,且联合组明显低于温针组[白介素-17(IL-17):(94.41±15.37)pg/mL vs(112.15±17.48)pg/mL、白介素-22(IL-22):(42.75±10.38)pg/mL vs(58.48±11.92)pg/mL、白介素-23(IL-23):(32.95±8.16)pg/mL vs(43.11±9.45)pg/mL、白介素-1β(IL-1β):(22.17±6.35)pg/mL vs(37.24±7.44)pg/mL],差异均有统计学意义(P<0.05);治疗后,两组患者的DLQI评分较治疗前降低,SF-36评分较治疗前升高,且联合组患者的DLQI评分明显低于温针组[(4.15±1.35)分vs(6.44±1.23)分],SF-36评分明显高于温针组[(52.85±6.37)分vs(45.19±5.21)分],差异均有统计学意义(P<0.05);两组患者治疗期间均无重大不良反应发生。结论腰腿痛贴膏联合温针治疗PA能进一步提高临床疗效,降低中医症候评分,抑制Th17细胞因子,提高生活质量,且安全性较佳。Objective To investigate the effect of Yaotuitong Plaster combined with warm needling on TCM symptom scores,Th17 cytokines,and quality of life of patients with psoriatic arthritis(PA).Methods A total of 76 patients with PA admitted to Shaanxi Provincial Hospital of Chinese Medicine from May 2020 to May 2021 were selected.They were randomly divided into warm needling group and combined group,with 38 patients in each group.The patients in the warm needling group was treated with warm needling,once a day,10 times as a course of treatment,with 3 d of interval between two courses.The patients in the combined group was treated with Yaotuitong Plaster based on warm needling group,once every 3 days,for 3 months.The curative effect after treatment,TCM symptom scores,Th17 cytokines,quality of life,and adverse reactions before and after treatment were compared between two groups.The curative effect was evaluated with the reduction rate of TCM symptom scores.Th17 cytokines were detected by ELISA.The quality of life was evaluated by Dermatology Life Quality Index(DLQI)and Short-Form 36(SF-36).Results The total effective rate in the combined group was 89.47%,which was significantly higher than 71.05%in the warm needling group(P<0.05).After treatment,TCM symptom scores of the two groups decreased compared with those before treatment,and the scores in the combined group were significantly lower than those in the warm needling group,with statistically significant differences(P<0.05).After treatment,Th17 cytokines were decreased in two groups compared with those before treatment,and the levels of interleukin-17(IL-17),interleukin-22(IL-22),interleukin-23(IL-23)and interleukin-1β(IL-1β)in the combined group were(94.41±15.37)pg/mL,(42.75±10.38)pg/mL,(32.95±8.16)pg/mL,(22.17±6.35)pg/mL,which were significantly lower than(112.15±17.48)pg/mL,(58.48±11.92)pg/mL,(43.11±9.45)pg/mL,(37.24±7.44)pg/mL in the warm needling group(P<0.05).After treatment,the DLQI scores of the two groups were lower than those before treatment,and the

关 键 词：关节型银屑病 腰腿痛贴膏 温针 中医症候 Th17细胞因子 生活质量 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]