新生儿窒息后心肌损害的相关危险因素分析  

Risk factors of myocardial damage after neonatal asphyxia

作　　者：许元杰 丁海燕 袁华兵[2] 王春秀[2] 徐会荣[2] XU Yuan-jie;DING Hai-yan;YUAN Hua-bing;WANG Chun-xiu;XU Hui-rong(Wuhan University of Science and Technology,Wuhan 430065,Hubei,CHINA;Tianmen First People's Hospital,Tianmen 431700,Hubei,CHINA)

机构地区：[1]武汉科技大学,湖北武汉430065 [2]天门市第一人民医院,湖北天门431700

出　　处：《海南医学》2023年第7期974-977,共4页Hainan Medical Journal

基　　金：湖北省卫生计生科研基金资助项目(编号:WJ2019H209)。

摘　　要：目的研究新生儿窒息后发生心肌损害的危险因素。方法回顾性分析2018年11月至2020年11月天门市第一人民医院新生儿科收治的156例窒息患儿的临床资料,其中非心肌损害患儿89例(非心肌损害组),发生心肌损害患儿67例(心肌损害组)。比较两组患儿的基本特征、母亲基本特征及母亲分娩时情况,并采用单因素分析新生儿窒息后心肌损害的相关因素,再采用多因素Logistic回归分析窒息新生儿发生心肌损害的独立危险因素。结果经单因素分析结果显示,有意义的变量为7个,分别为胎龄、早产儿、低出生体质量儿、孕妇的年龄、羊水异常、宫内窘迫、窒息程度;经Logistic回归分析结果显示,窒息新生儿发生心肌损害的相关危险因素比值比(OR)从大到小依次为羊水异常(OR=4.951)、母亲年龄(OR=3.191)、宫内窘迫(OR=3.172)。结论窒息新生儿发生心肌损害与多种因素有关,及早发现可能导致心肌损害的异常状况,尽早进行干预,以减少窒息新生儿心肌损害的发生率,降低窒息新生儿致残率、死亡率。Objective To study the risk factors of myocardial damage after neonatal asphyxia.Methods The medical records of 156 asphyxiated children admitted to Department of Neonatology,Tianmen First People's Hospital from November 2018 to November 2020 were retrospectively analyzed,including 89 children with non-myocardial damage(non-myocardial damage group)and 67 children with myocardial damage(myocardial damage group).The basic characteristics of the two groups of children,the basic characteristics of mothers,and the situation of the mother during delivery were compared.Single factor analysis was used to analyze the related factors of myocardial damage after neonatal asphyxia,and multifactor logistic regression analysis was used to analyze the independent risk factors of myocardial damage in asphyxiated neonates.Results Single factor analysis showed that there were 7 significant variables,including gestational age,premature infants,low birth weight infants,age of pregnant women,abnormal amniotic fluid,intrauterine distress,and asphyxia degree.Logistic regression analysis showed that the relative risk factors of myocardial damage in asphyxiated neonates were abnormal amniotic fluid(OR=4.951),maternal age(OR=3.191),and intrauterine distress(OR=3.172),respectively.Conclusion The occurrence of myocardial damage in asphyxiated neonates is related to many factors.Early detection of abnormal conditions that may lead to myocardial damage and early intervention can reduce the incidence of myocardial damage in asphyxiated neonates,and reduce the morbidity and mortality of asphyxiated neonates.

关 键 词：新生儿 窒息 心肌损害 危险因素 

分 类 号：R722.12[医药卫生—儿科]