西安地区Stago-R(max)凝血仪健康成人和老年人凝血功能指标参考区间的建立  

Establishment of reference interval of coagulation function indicators of Stago-R(max)coagulation instrument in healthy adults and the elderly in Xi'an area

作　　者：陈楚 袁莉[2] 张可可 李华 CHEN Chu;YUAN Li;ZHANG Ke-ke;LI Hua(Department of Clinical Laboratory,Shaanxi Hospital of Traditional Chinese Medicine,Xi'an 710003,Shaanxi,CHINA;Department of Clinical Laboratory,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi,CHINA;Department of Clinical Laboratory,Fugu County People's Hospital,Fugu 719400,Shaanxi,CHINA)

机构地区：[1]陕西省中医医院检验科,陕西西安710003 [2]西安交通大学第一附属医院检验科,陕西西安710061 [3]府谷县人民医院检验科,陕西府谷719400

出　　处：《海南医学》2023年第7期994-997,共4页Hainan Medical Journal

摘　　要：目的建立Stago-R(max)凝血仪成年人和老年人凝血指标的参考区间。方法选取2021年5~7月期间分别在西安地区陕西省中医医院、西安交通大学第一附属医院体检或就诊的人员,根据年龄分为成人组(≥18岁,<60岁,180例)和老年人组(≥60岁,150例),使用Stago-R(max)凝血分析仪检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB),非参数法分析各参数的参考区间。结果老年组相对成年组PT、TT缩短,APTT延长,FIB更高,差异均存在统计学意义;Stago-R(max)凝血分析仪各指标的参考区间分别为:成人组,PT,11.68~14.35 s,APTT,28.6~41.75 s,TT,15.6~18.54 s,FIB,1.95~4.59 g/L,老年组,PT,11~13.72 s,APTT,30.86~39.75 s,TT,15.08~18.37 s,FIB,2.18~3.95 g/L。结论成年组与老年组凝血四项的结果存在差异,可根据临床需求设立不同年龄段的参考区间,自建参考区间与厂家SOP提供的存在差异,同地域同系统凝血项目参考区间的统一有利于区域内检验结果互认的开展。Objective To establish the reference interval of coagulation indexes in the adult and the elderly of Stago-R(max)coagulation instrument in the adult and the elderly.Methods According to the inclusion and exclusion criteria,330 patients≥18 years old in Shaanxi Hospital of Traditional Chinese Medicine and the First Affiliated Hospital of Xi'an Jiaotong University were selected from May 2021 to July 2021 in Xi'an,including 180 patients in the adult group(≥18 years,<60 years)and 150 patients in the elderly group(≥60 years).Stago-R(max)coagulation instruments were used to detect prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB),and the reference interval of each parameter was statistically analyzed by the nonparametric method.Results Compared with the adult group,PT and TT were shortened,APTT was prolonged,and FIB was higher in the elderly group,and the differences were statistically significant.The reference intervals of parameters of Stago-R(max)coagulation instrument in different age groups were as follows:the adult(PT:11.68-14.35 s,APTT:28.6-41.75 s,TT:15.6-18.54 s,FIB:1.95~4.59 g/L),the elderly(PT:11-13.72 s,APTT:30.86-39.75 s,TT:15.08-18.37 s,FIB:2.18-3.95 g/L).Conclusion There are differences in the results of the four coagulation items between the adult group and the elderly group.Reference intervals for different age groups can be established according to clinical needs.There are differences between the self-built reference and the intervals provided by SOP of the manufacturer.The unification of the reference intervals of coagulation items in the same region and system is conducive to the development of mutual recognition of test results in the region.

关 键 词：西安 凝血功能指标 参考区间 非参数法 Stago-R(max)凝血仪 

分 类 号：R457.2[医药卫生—治疗学]