BMP-2在骨骼生长发育中的作用及研究进展  

Role and research progress of bone morphogenetic protein 2 in bone growth and development

作　　者：郑潇飞(综述) 程姣 罗祥友 蒋练(审校) ZHENG Xiao-fei;CHENG Jiao;LUO Xiang-you;JIANG Lian(The Affiliated Stomatological Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,CHINA)

机构地区：[1]遵义医科大学附属口腔医院,贵州遵义563000

出　　处：《海南医学》2023年第7期1047-1051,共5页Hainan Medical Journal

基　　金：贵州省科技计划项目(编号:黔科合基础-ZK【2021】一般432);贵州省卫生健康委科学技术基金项目(编号:gzwkj2021-344);贵州遵义市科技计划项目资助(编号:遵市科合社字【2018】246号)。

摘　　要：骨形态发生蛋白(BMPs)是一类多功能的生长因子,属于转化生长因子-β(TGF-β)超家族,其在心脏、神经、软骨的形成以及成骨等发育过程中都是必不可少的。而骨形态发生蛋白2(BMP-2)作为第一个被发现的BMP,近年来已被广泛研究,其在骨骼发育、成年后骨形成与改建过程中发挥着关键性作用。本文就BMP-2的结构与功能、其激活和调节的信号通路、临床应用和并发症等方面做一综述,旨在为基础研究和临床治疗提供帮助。Bone morphogenetic proteins(BMPs)are multi-functional growth factors that belong to the transforming growth factorβ(TGF-β)superfamily.These proteins are essential to many developmental processes,including cardiogenesis,neurogenesis,chondrogenesis,and osteogenesis.Bone morphogenetic protein-2(BMP-2),as the first BMP discovered,has been extensively studied in recent years.It plays a key role in the process of skeletal development,bone formation and remodeling in adulthood.This article reviews the structure and function of BMP-2,its activation and regulation signaling pathways,and clinical applications and complications,in order to provide help for clinical treatment and basic research.

关 键 词：成骨 发育 骨形态发生蛋白2 转化生长因子-β信号通路 WNT信号通路 临床应用 

分 类 号：R681[医药卫生—骨科学]