外泌体源miRNA在宫腔黏连中的研究进展  

Research progress on exosome-derived miRNAs in intrauterine adhesions

作　　者：梁恩铭(综述) 沈媛(审校)[1] LIANG En-ming;SHEN Yuan(Department of Gynecology,the First Affiliated Hospital of Jinan University,Guangzhou 510632,Guangdong,CHINA)

机构地区：[1]暨南大学附属第一医院妇科,广东广州510632

出　　处：《海南医学》2023年第7期1061-1064,共4页Hainan Medical Journal

基　　金：广东省广州市校(院)联合资助项目基础与应用基础研究(编号:202201020044)。

摘　　要：外泌体是一种富含蛋白质、脂质、RNA等多种功能活性物质的细胞外囊泡,通过传递生物信号分子在人类疾病的发生发展中起着关键的调控作用。外泌体源miRNA是一类可调控靶基因的小分子非编码单链RNA,可在转录水平调控蛋白表达。研究证实,外泌体源miRNA与宫腔黏连的发生密切相关,可能对该疾病的治疗产生重大影响。本文就外泌体源miRNA在宫腔黏连发生发展中所扮演的角色及其潜在的临床应用价值进行综述。Exosomes are an extracellular vesicle rich in proteins,lipids,RNA,and other functional active substances,which play a key regulatory role in the occurrence and development of human diseases by transmitting biological signaling molecules.Exosome-derived miRNA is a class of small-molecule non-coding single-stranded RNA that regulates target genes to regulate protein expression at the transcriptional level.Studies have confirmed that exosome-derived miRNA is closely related to the occurrence of intrauterine adhesions,and may have a significant impact on the treatment of this disease.This paper reviews the role of exosome-derived miRNA in the development of intrauterine adhesions and its potential clinical application value.

关 键 词：外泌体 微小RNA 外泌体源miRNA 宫腔黏连 上皮间质转化 

分 类 号：R711.74[医药卫生—妇产科学]