脂肪血管基质组分在呼吸系统疾病中的应用  

Applications of stromal vascular fractions in respiratory diseases

作　　者：都昇 宋新宇 李时悦[1] Du Sheng;Song Xinyu;Li Shiyue(Departmentof Respiratory and Critical Care Medicine,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Health,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine,National Clinical Research Center for Respiratory Disease,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院呼吸与危重症医学科、广州呼吸健康研究院、呼吸疾病国家重点实验室、国家呼吸医学中心国家呼吸系统疾病临床医学研究中心,广州510120

出　　处：《国际呼吸杂志》2023年第3期365-368,共4页International Journal of Respiration

基　　金：广州市科技计划项目(202102010358);广东省教育厅呼吸疾病再生医学创新团队(2021KCXTD028);广州呼吸健康研究院自主立项课题项目(ZNSA-2020013)。

摘　　要：脂肪血管基质组分(SVF)是从脂肪组织提取出来的含有基质细胞、内皮祖细胞、内皮细胞、成纤维细胞、周细胞、巨噬细胞、淋巴细胞等多种组分的一组异质性细胞群。其中含有的多组分细胞通过免疫调节损伤部位的免疫微环境,支持损伤组织的修复,使之恢复正常的形态及功能。脂肪SVF已在慢性阻塞性肺疾病、特发性肺纤维化和气道瘘等呼吸系统疾病的治疗中进行了探索,初步证实了可行性、安全性及初步的疗效。本文综述了脂肪SVF的特点、提取方法,以及其在呼吸系统疾病临床研究中的应用,为更规范的使用脂肪SVF治疗相关疾病提供启示。Stromal vascular fractions(SVF)are isolated from adipose tissues,containing heterogeneous cell populations of adipose-derived stromal cells,endothelial progenitor cells,endothelial cells,fibroblasts,pericytes,macrophages and lymphocytes.The multi-components contribute to the repair of injured tissues to return normal morphology and functions via mediating the immune microenvironment in the lesions.The role of SVF from adipose tissues in the treatment of chronic obstructive pulmonary diseases,idiopathic pulmonary fibrosis,respiratory tract fistula and other respiratory diseases has been explored,and their feasibility,safety and therapeutic efficacy have been validated.This review describes the biological features,isolation methods,and clinical applications of SVF in respiratory diseases,which provide references for the standardized therapeutics of adipose-derived SVF.

关 键 词：肺疾病 慢性阻塞性 特发性肺纤维化 呼吸道瘘 免疫调节 脂肪组织 

分 类 号：R56[医药卫生—呼吸系统]