儿童肾移植术后急性排斥反应的特点及思考  

Characteristics and thinking of acute rejection after pediatric kidney transplantation

作　　者：陈刚[1] Chen Gang(Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology Key Laboratory of Organ Transplantation,Ministry of Education Ministry of Health Chinese Academy of Medical Sciences,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院器官移植研究所,器官移植教育部重点实验室,国家卫生健康委员会器官移植重点实验室,中国医学科学院器官移植重点实验室,武汉430030

出　　处：《中华器官移植杂志》2023年第2期65-67,共3页Chinese Journal of Organ Transplantation

基　　金：华中科技大学同济医学院附属同济医院临床研究领航项目(2019CR108)。

摘　　要：得益于"儿童供肾优先分配给儿童受者"的现行国家器官分配政策,我国儿童肾移植得到了快速的发展,但儿童肾移植的效果还有待进一步系统总结。本文通过总结儿童免疫系统的特点及相关研究进展、儿童肾移植术后急性排斥反应的发生率及影响因素,比较兔抗人胸腺细胞免疫球蛋白及抗CD25单抗诱导治疗对儿童肾移植术后急性排斥反应的预防效果,并对其未来的应用提出建议。Because of the current national organ allocation policy of"pediatric donor kidneys are given priority to pediatric recipients",Chinese pediatric kidney transplantation has achieved rapid development,but the outcomes of pediatric kidney transplantation need to be further systematically summarized.In this paper,by summarizing the characteristics of children's immune system and related research progress,the incidence and influencing factors of acute rejection after pediatric kidney transplantation,the prevention effects of rabbit anti-human thymocyte immunoglobulin(rATG)and anti-CD25 monoclonal antibody induction therapy on acute rejection after pediatric kidney transplantation were compared,and suggestions were put forward for their future application.

关 键 词：儿童 肾移植 急性排斥反应 免疫诱导治疗 

分 类 号：R726.9[医药卫生—儿科]